Study on the Assessment of Fetal Growth Restriction and Pregnancy Outcome by Color Doppler Ultrasound Combined with Serum Pregnancy-Associated Plasma Protein A
Objective:To explore the value of color Doppler ultrasound combined with serum pregnancy-associated protein A(PAPP-A)on evaluating fetal growth restriction(FGR)and pregnancy outcomes.Methods:The clinical data of 1465 pregnant women in the first trimester who were admitted to our hospital were retrospectively analyzed from May 2021 to May 2023.All patients underwent color Doppler ultrasound ex-amination after enrollment,and serum PAPP-A was detected.According to the status of FGR,the patients were divided into restricted group(n=105)and normal group(n=1360).The ultrasound examination results and serum PAPP-A level were compared between the two groups.ROC curve was used to analyze the predic-tive efficiency of ultrasound examination and serum PAPP-A level at admission on FGR.By means of the pregnancy outcomes,the pregnant women in growth restriction group were classified into abnormal pregnancy outcome subgroup and normal delivery subgroup,and the ultrasound results and serum PAPP-A level were compared between the two subgroups.ROC curve was applied to analyze the predictive efficiency of ultrasound examination and serum PAPP-A level at admission on pregnancy outcomes.Results:The UtA-PI and UtA-RI in restricted group were significantly higher than those in normal group while serum PAPP-A level was sig-nificantly lower than that in normal group(P<0.05).ROC curve analysis showed that the AUCs of UtA-PI,UtA-RI and serum PAPP-A for predicting FGR were 0.759,0.631 and 0.855 respectively(P<0.05).The UtA-PI and UtA-RI in abnormal pregnancy outcome subgroup were significantly higher while the level of ser-um PAPP-A was significantly lower compared to normal delivery subgroup(P<0.05).ROC curve analysis revealed that the AUCs of UtA-PI,UtA-RI and serum PAPP-A were 0.712,0.692 and 0.658 respectively in predicting abnormal pregnancy outcomes(P<0.05).Conclusion:UtA-PI,UtA-RI values,and serum PAPP-A are closely related to the occurrence of fetal FGR and have high clinical value on predicting the preg-nancy outcomes of pregnant women.
Color doppler ultrasoundSerum pregnancy-associated protein AFetal growth re-strictionPregnancy outcomes
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