Changes in the Fractional Amplitude of Low-Frequency Fluctuations in Patients with Cerebellar Infarction on Different Sides and Its Association with Cognitive Function Changes
Objective:To investigate the changes in the fractional amplitude of low-frequency fluctua-tions(fALFF)values in different brain regions of patients with cerebellar infarction on different sides and its association with changes in cognitive function.Methods:A retrospective study was conducted on 92 patients with acute unilateral cerebellar infarction diagnosed in the Department of Neurology of our hospital from April 2022 to March 2024.Patients were divided into left-side group(45 cases)and right-side group(47 cases)based on the location of the infarction.An additional 50 healthy individuals were selected as the healthy con-trol group.Cognitive function scores were compared between different groups,and differences in fALFF values between the left-side and right-side groups were analyzed,along with the correlation between fALFF values in different brain regions and cognitive function.Results:The MMSE scores,RAVLT scores,and BNT scores of patients in the cerebellar infarction group were significantly lower than those in the healthy control group(P<0.05),and the TMT time was significantly prolonged compared to the control group(P<0.05).The fALFF values of the right cingulate gyrus,right inferior frontal gyrus,left superior frontal gyrus,and cerebellar poste-rior lobe in the cerebellar infarction group were significantly higher compared to the healthy control group(P<0.05).In the left-side group,the fALFF values of the right cingulate gyrus,inferior frontal gyrus,and left superior frontal gyrus were significantly higher than those in the right-side group(P<0.05),while the fALFF value of the cerebellar posterior lobe was significantly lower compared to the right-side group(P<0.05).In the right-side group,the fALFF value of the right frontal lobe was positively correlated with MMSE scores(P<0.05),and the right inferior parietal lobule was negatively correlated with MMSE scores(P<0.05).The left anterior cingulate gyrus was positively correlated with RAVLT scores(P<0.05),and the left parietal lobe was negatively correlated with TMT time(P<0.05).In the left-side group,the right prefrontal lobe,inferior parietal lobule,and cingulate gyrus were negatively correlated with MMSE scores(P<0.05),the right inferior parietal lobule was negatively correlated with RAVLT scores(P<0.05),the right occipital lobe was positively correlated with RAVLT scores(P<0.05),and the right parietal lobe was positively correlated with TMT time(P<0.05).Conclusion:Compared to healthy individuals,cognitive function in patients with cerebellar in-farction is significantly reduced.At the same time,the fALFF values in key brain regions on the contralateral side of the infarction show significant compensatory increases,which are strongly correlated with cognitive function levels.
Cerebellar infarctionBrain regionsFractional amplitude of low-frequency fluctua-tionsCognitive function
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