Effects of Es-ketamine Combined with Propofol Anesthesia on Stress Levels Cognitive Function,and Serum BDNF and NSE Levels in Elderly Patients Undergoing Radical Mastectomy for Breast Cancer
Objective:To investigate the effects of es-ketamine combined with propofol anesthesia on stress levels,cognitive function,and serum BDNF and NSE levels in elderly patients undergoing radical mas-tectomy for breast cancer.Methods:Ninety elderly patients who underwent radical mastectomy for breast cancer at our hospital from May 2020 to July 2022 were selected and further divided into the observation group(45 cases,es-ketamine combined with propofol)and the control group(45 cases,propofol anesthesia)ac-cording to a random number table method.The stress levels,cognitive function,and serum BDNF and NSE levels of the two groups were compared.Results:In the observation group,cortisol and adrenaline levels at T2,T3,and T4 time points were significantly higher compared to T0 time point(P<0.05).In the control group,cortisol and adrenaline levels at T1,T2,T3,and T4 time points were significantly higher compared to T0 time point(P<0.05).The increase in cortisol and adrenaline levels at T1,T2,T3,and T4 time points in the observation group was significantly lower than that in the control group(P<0.05).Both groups showed a decrease in cognitive function scores and BDNF levels and an increase in NSE levels at 24h and 48h postoper-atively,with the observation group showing better changes than the control group(P<0.05).The awakening,extubation,and orientation recovery times in the observation group were significantly shorter than those in the control group(P<0.05).Conclusion:Es-ketamine combined with propofol anesthesia in elderly patients un-dergoing radical mastectomy for breast cancer can reduce the body's stress response,accelerate cognitive func-tion recovery,and improve the quality of postoperative awakening.
Elderly radical mastectomy for breast cancerPropofolEs-ketamineStress lev-elsCognitive function
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