Clinical Efficacy of Compound Betamethasone Combined with Iliac Fascia Block in Postoperative Analgesia for Patients Undergoing Total Hip Arthroplasty:Effects on TLR4/NF-κB Signaling Pathway
Objective:To explore the clinical value of compound betamethasone combined with iliac fas-cia block in postoperative analgesia for patients undergoing total hip arthroplasty(THA),and its influence on the TLR4/NF-κB signaling pathway.Methods:A total of 152 patients undergoing THA from November 2022 to December 2023 were included in this study.Patients were randomly divided into two groups:the control group received iliac fascia block,and the experimental group received compound betamethasone and iliac fas-cia block.Parameters compared between the two groups included perioperative indicators,pain scores,hip joint mobility,TLR4/NF-κB signaling pathway factors,and incidence of adverse reactions.Results:Meth-ods:There were no significant differences between two groups in terms of operation time,blood loss,anesthe-sia time,time to first ambulation,and intraoperative fluid infusion(P＞0.05).Pain scores at 24 hours and 48 hours postoperatively were significantly lower in the experimental group than in the control group(P＜0.05),while there was no significant difference in pain scores at 2 hours postoperatively between the two groups(P＞0.05).At 7 days and 14 days postoperatively,hip joint mobility was significantly higher in the experimental group compared to the control group,and at 14 days postoperatively,hip joint mobility improved significantly in both groups(P＜0.05).Serum levels of TLR4 and NF-κB at 24 hours and 48 hours postoperatively were significantly lower in the experimental group than in the control group(P＜0.05),while there was no signifi-cant difference in serum levels of TLR4 and NF-κB before surgery between the two groups(P＞0.05).During treatment,neither group experienced adverse reactions such as nausea,vomiting,or itching.Conclusion:Compound betamethasone combined with iliac fascia block effectively reduces pain intensity,improves hip joint mobility,and is associated with the expression of TLR4/NF-κB signaling pathway in patients undergoing THA,demonstrating safety and efficacy.
Total hip arthroplastyCompound betamethasoneIliac fascia blockAnalgesiaToll-like receptor 4NF-κB
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