Expression of STAT3 and ADAMTS19 in Endometrial Cancer Tissues and Their Relationship with Pathological Parameters and Prognosis
Objective:To investigate the expression of signal transducer and activator of transcription 3(STAT3)and A disintegrin and metalloproteinase with thrombospondin motifs 19(ADAMTS19)in endometri-al carcinoma(EC)tissues and the relationship with pathological parameters and prognosis.Methods:A total of 82 patients with EC who underwent surgical resection in our hospital from January 2018 to December 2020 were selected.Immunohistochemistry was used to detect the expression of STAT3 and ADAMTS19 in EC tis-sues and paracancerous tissues.The correlation between STAT3 and ADAMTS19 expression in EC tissues was analyzed using Phi correlation coefficient.According to the expression of STAT3 and ADAMTS19 in EC tis-sues,the patients were divided into STAT3 and ADAMTS19 positive/negative expression groups.Kaplan-Meier method was used to draw the survival curves of EC patients with STAT3 and ADAMTS19 positive/nega-tive expression,and Cox regression analysis was used to analyze the factors affecting the prognosis of EC pa-tients;ROC curve was used to evaluate the predictive value of STAT3 and ADAMTS19 expression in cancer tissues for the death of EC patients.Results:Compared with paracancerous tissues,the positive expression rate of STAT3 in EC tissues was increased,and the positive expression rate of ADAMTS19 was decreased(P＜0.05).The expression of STAT3 and ADAMTS19 in EC tissues was negatively correlated(φ=-0.443,P＜0.001).The expression of STAT3 and ADAMTS19 was related to the International Federation of Gynecology and Obstetrics(FIGO)stage,depth of myometrial invasion,degree of differentiation and lymph node metasta-sis of EC patients(P＜0.05).The 3-year overall survival rate of the 82 patients with EC was 69.51％(57/82).The 3-year overall survival rate of the STAT3 positive expression group was 60.71％,which was lower than that of the STAT3 negative expression group(88.46％),and the 3-year overall survival rate of the AD-AMTS19 positive expression group was 88.89％,which was higher than that of the ADAMTS19 negative ex-pression group(64.06％)(P＜0.05).FIGO stage Ⅲ,myometrial invasion depth ≥ 1/2,low differentiation,lymph node metastasis and STAT3 positive expression were independent risk factors for the death of EC pa-tients,and ADAMTS19 positive expression was an independent protective factor(P＜0.05).The area under the curve(AUC)of the joint prediction of STAT3 and ADAMTS19 expression in cancer tissues for the death of EC patients was 0.860,which was greater than that of the separate prediction of STAT3 and ADAMTS19 ex-pression in cancer tissues(0.758,0.750)(P＜0.05).Conclusion:STAT3 was highly expressed and AD-AMTS19 was lowly expressed in EC tissues,and their expressions were negatively correlated.They were sig-nificantly related to FIGO stage,depth of myometrial invasion,degree of differentiation,lymph node metasta-sis and prognosis.The joint expression of STAT3 and ADAMTS19 had a high predictive value for the prognosis of EC patients.
Endometrial cancerSignal transducer and activator of transcription 3A disintegrin and metalloproteinase with thrombospondin motifs 19Pathological parametersPrognosis
万方数据
维普
