Analysis of CT Segmental Texture Characteristics and Relationship with Pulmonary Function Indices in COPD Patients
Objective:To analyze the CT segmented texture characteristics and the relationship with pul-monary function indicators in patients with chronic obstructive pulmonary disease(COPD).Methods:From March 2022 to March 2023,80 patients with COPD were selected as the study subjects(study group),and 60 healthy people who received physical examination in the hospital were included in the control group.All pa-tients underwent high-resolution CT scans and CT segmented texture characteristics and pulmonary function tests.The pulmonary function indicators[forced expiratory volume in the first second as a percentage of pre-dicted value FEV1%),forced vital capacity(FVC),FEV1/FVC]and texture characteristics of the whole lung region and the outer lung region were compared between the two groups The correlation between CT tex-ture characteristics and pulmonary function indicators was analyzed.Results:There were no statistical differ-ences in age and gender between groups(P＞0.05).The FEV1%,FVC,and FEV1/FVC in the study group were lower than those in the control group(P＜0.05).The whole lung GLCM contrast,whole lung GLCM en-tropy,whole lung GLSZM area size non-uniformity,outer lung GLCM contrast,outer lung GLCM entropy,outer lung GLSZM area size non-uniformity,and outer lung LBP eigenvalue in the study group were higher than those in the control group(P＜0.05).Pearson correlation analysis showed that whole lung GLCM con-trast,whole lung GLCM entropy,whole lung GLSZM area size non-uniformity,outer lung GLCM contrast,outer lung GLCM entropy,outer lung GLSZM area size non-uniformity,and outer lung LBP eigenvalue were negatively correlated with FEV1%,FVC and FEV1/FVC(P＜0.05).Multivariate regression analysis showed that whole lung GLCM contrast,whole lung GLCM entropy,whole lung GLSZM area size non-uniformity,out-er lung GLCM contrast,outer lung GLCM entropy,outer lung GLSZM area size non-uniformity,and outer lung LBP eigenvalue had significant effects on FEV1%,FVC and FEV1/FVC in patients with COPD(P＜0.05),and the R2 values were 0.682,0.657 and 0.715 respectively,suggesting that the model had high good-ness of fit.Conclusion:CT segmented texture characteristics are closely related to pulmonary function indica-tors of COPD patients.The GLCM contrast,GLCM entropy,GLSZM area size non-uniformity,and LBP ei-genvalue of the whole lung and outer lung can be used as important reference indicators for imaging evaluation and early diagnosis of COPD.
High-resolution CTTexture characteristics analysisChronic obstructive pulmonary diseasePulmonary function
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