Effect of Tiotropium Bromide Combined with Budesonide Inhalation Therapy on Lung Function and Sleep Quality in Patients with Asthma-Colonial Overlap Syndrome
Objective:To evaluate the effect of tiotropium bromide combined with budesonide inhalation therapy on lung function and sleep quality in patients with asthma-chronic obstructive pulmonary disease over-lap syndrome(ACOS).Methods:A total of 98 ACOS patients treated in our hospital from January 2019 to January 2024 were sampled.They were divided into two groups using the random number table method,with 49 cases in each group.The control group was treated with budesonide inhalation,and the observation group was treated with tiotropium bromide based on the control group.Both groups were treated for 3 months.The two groups of patients were compared before and after treatment in terms of inflammation levels[interleukin 6(IL-6),tumor necrosis factor alpha(TNF alpha),hypersensitive c-reactive protein(hs-CRP)],im-mune function[17(Th17 and regulatory T helper T cells,of Th17/Treg cells(Treg)],airway remodeling factor[transforming growth factor beta 1-(TGF β1)and osteopontin(OPN)and matrix metalloproteinases 9(MMP 9)],lung function(forced expiratory volume in 1 second(FEV1)and forced vital capacity(FVC),and the largest independent ventilation per minute(MVV).Chronic obstructive pulmonary disease(CAT)score and asthma symptom score(ACT)were used to evaluate the disease symptoms before and after treat-ment,and Pittsburgh Sleep Quality Index(PSQI)scale was used to compare the sleep quality of the two groups after 3 months of treatment.Results:Before treatment,there were no significant differences in serum inflammatory factors,Th17,Th17/Treg,airway remodeling factors,lung function,CAT,and PSQI scores be-tween the two groups(P＞0.05).Compared with before treatment,the serum IL-6,TNF-α,hs-CRP,Th17,Th17/Treg,TGF-β1,OPN,MMP-9 levels,ACT and CAT scores in both groups were decreased after treatment,while Treg level,lung function FEV1,FVC,and MVV levels were increased.The difference was statistically significant(P＜0.05).There were statistically significant differences in serum inflammatory fac-tors,Th17,Th17/Treg,airway remodeling factors,lung function,CAT,and PSQI scores before and after treatment between the two groups(P＜0.05).The sleep status of the observation group after treatment was better than that of the control group,and the difference was statistically significant(P＜0.05).Conclusion:The combination of tiotropium and budesonide in the treatment of ACOS helps improve lung function and sleep quality.
TiotropiumBudesonideAsthma obstructive pulmonary disease overlap syn-dromePulmonary functionQuality of sleep
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