Correlation of Th1/Th2 Balance and HLA-DQA1 Gene Polymorphism with Hemodialysis Catheter-Related Infections
Objective:To explore the correlation between Th1/Th2 balance,human leukocyte antigen DQA1(HLA-DQA1)gene polymorphism,and catheter-related infections during hemodialysis.Methods:Forty-eight patients with hemodialysis catheter-related infections treated at our hospital from January 2020 to January 2024 were selected as the observation group.Two hundred sixty patients undergoing hemodialysis without catheter-related infections during the same period were selected as the control group.The differences in Th1 cells,Th2 cells,associated cytokines,and HLA-DQA1 gene polymorphisms between the two groups were compared.Results:The Th1,Th2,TNF-α,TGF-1,IL-4,and IL-6 levels in the observation group were(43.35±9.10)%,(3.10±0.92)%,(46.22±8.87)pg/mL,(50.05±13.36)pg/mL,(1.03±0.35)pg/mL,and(40.05±11.65)pg/mL,respectively,higher than those in the control group(P＜0.05),while Th1/Th2 levels were(14.01±2.20),lower than those in the control group(P＜0.05).There was a statisti-cally significant difference in HLA-DQA1 genotype between the observation group and the control group(P＜0.05).The TNF-α,IL-4,and IL-6 of the observation group's deceased patients were(58.07±2.65)pg/mL,(1.22±0.21)pg/mL,and(46.67±9.96)ng/L,respectively,higher than those of the surviving pa-tients(P＜0.05).There was no statistically significant difference in HLA-DQA1 gene polymorphism between surviving and deceased patients in the observation group(P＞0.05).Conclusion:Patients with hemodialysis catheter-related infections exhibit elevated levels of Th1 cells,Th2 cells,and associated factors.There are differences in HLA-DQA1 genotypes between patients with and without infections,with TNF-α,IL-4,and IL-6 levels associated with prognosis.
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