Correlation Study of Platelet Parameters NF-κB IL-6 Levels with Disease Severity and Prognosis in Patients with Cirrhosis Complicated by Upper Gastrointestinal Bleeding
Objective:To analyze the correlation between platelet parameters,serum nuclear factor-κB(NF-κB),interleukin-6(IL-6)levels,and the disease severity and prognosis in patients with cirrhosis complicated by upper gastrointestinal bleeding(UGIB).Methods:A total of 155 patients with cirrhosis com-plicated by UGIB,treated at our hospital from January 2021 to January 2024,were included in the study.Based on the amount of blood loss before admission,they were divided into a mild group(n=70)and a mod-erate to severe group(n=85).Additionally,based on the prognosis,they were categorized into a good prog-nosis group(n=122)and a poor prognosis group(n=33).Platelet parameters[platelet count(PLT),mean platelet volume(MPV),plateletcrit(PCT),platelet distribution width(PDW)],serum NF-κB,and IL-6 levels were measured in all patients.Spearman rank correlation analysis was used to evaluate the relationship between these parameters and the severity and prognosis of cirrhosis complicated by UGIB.Results:The PLT,MPV,PCT,PDW,serum NF-κB,and IL-6 levels in the moderate to severe group were significantly higher than those in the mild group(P＜0.05).Similarly,these parameters were higher in the poor prognosis group compared to the good prognosis group(P＜0.05).Spearman rank correlation analysis indicated a posi-tive correlation between PLT,MPV,PCT,PDW,serum NF-κB,IL-6 levels,and the severity of cirrhosis complicated by UGIB(r=0.226,0.311,0.387,0.311,0.351,0.386;P＜0.05).Conclusion:Platelet pa-rameters,NF-κB,and IL-6 levels are closely related to the severity and prognosis of patients with cirrhosis complicated by UGIB.Early detection of these serum indicators can provide a reference for clinical assessment of disease severity and prognosis.
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