Relationship between Serum COX-2 PTTG1 TLR4 Levels and Clinicopathological Features Prognosis and Survival of Primary Laryngeal Carcinoma
Objective:To investigate the relationship between serum cyclooxygenase-2(COX-2),pitu-itary tumor transforming gene 1(PTTG1),toll-like receptor 4(TLR4)levels and clinicopathological fea-tures,prognosis,and survival of primary laryngeal cancer.Methods:A total of 105 patients with primary la-ryngeal cancer and 105 patients with benign laryngeal lesions in Dazhou City Central Hospital of Sichuan Prov-ince from May 2021 to March 2023 were selected as observation and control groups,respectively.The serum COX-2,PTTG1 and TLR4 levels of the two groups were compared,and the relationship between serum COX-2,PTTG1 and TLR4 levels,and clinicopathological features was analyzed using multiple linear regression,and the prognostic survival rate of the patients with different serum COX-2,PTTG1,and TLR4 levels was compared in the follow-up of 3 years.Results:The levels of COX-2,PTTG1,and TLR4 in the observation group were(38.89±12.14)ng/L,(140.17±30.25)pg/mL,and(13.94±3.25)ng/mL,respectively,which were higher than those in the control group(17.63±5.09)ng/L,(98.49±15.63)pg/mL,and(8.72±2.13)ng/mL(t=16.549,12.543,13.765,all P<0.05).Multiple linear regression analysis showed that clinical stage(partial regression coefficient:0.714,0.722,0.719),tumor differentiation degree(partial re-gression coefficient:0.756,0.749,0.798),and lymph node metastasis(partial regression coefficient:0.802,0.798,0.713)were the influencing factors for the levels of serum COX-2,PTTG1,and TLR4 in pa-tients with primary laryngeal cancer(P<0.05).The 3-year overall survival rate and overall survival rate of the COX-2 high-level subgroup were 80.77%and 71.15%,respectively,which were significantly higher than those of the low-level subgroup 95.83%and 87.50%(P<0.05);the 3-year overall survival rate and o-verall survival rate of the PTTG1 high-level subgroup were 80.39%and 68.63%,respectively,which were significantly higher than those of the low-level subgroup 95.92%and 89.80%(P<0.05);3-year overall survival rate and overall survival rate of TLR4 high-level subgroup were 78.85%and 71.15%,respectively,which were significantly higher than those of 97.92%and 87.50%in the low-level subgroup(P<0.05).Conclusion:The levels of serum COX-2,PTTG1,and TLR4 are high in patients with primary laryngeal canc-er,and their high levels are related to clinical stage,tumor differentiation,and lymph node metastasis.Detec-tion of COX-2,PTTG1,and TLR4 levels can reflect the prognosis and survival of patients to a certain extent.
国家科技期刊平台
NSTL
万方数据
