Correlation between Serum Mir-647 Levels and In-Stent Restenosis after Bare Metal Stent Placement in Patients with Lower Limb Atherosclerotic Occlusive Disease
Objective:To explore and analyze the association between serum short non-coding RNA-647(miR-647)level and in-stent restenosis(ISR)in patients with lower extremity arteriosclerosis obliterans(ASO)after bare metal stent implantation.Methods:Totally 182 patients with lower extremity ASO in the hospital were enrolled from September 2020 to September 2023.Serum miR-647 level after bare metal stent implantation was detected,and the correlation between its level change and ISR was analyzed.Results:Out of 182 ASO patients,43 experienced ISR after metal bare stent implantation,with an incidence rate of 23.63%.The levels of miR-647,neutrophil to lymphocyte ratio(NLR),and C-reactive protein(CRP)in ISR pa-tients were significantly higher than those in non-ISR patients,with statistical significance(P<0.05).Univa-riate analysis showed statistical differences in Fontaine staging,age,hypertension,and diabetes mellitus be-tween ASO patients with postoperative ISR and patients without ISR(P<0.05).Person correlation analysis showed that miR-647 was positively correlated with NLR and CRP levels(r=0.351,0.402,P<0.05).Lo-gistic regression analysis showed that Fontaine staging,age,miR-647,NLR,CRP level,hypertension,and diabetes mellitus were risk factors for postoperative ISR in ASO patients(P<0.05).Concerning the ROC curve,the area under the curve(AUC),optimal cut-off value,sensitivity,and specificity of miR-647 ex-pression level in evaluating postoperative ISR were 0.767(95%CI:0.676-0.858),0.980,0.581 and 0.899 respectively.Conclusion:Serum miR-647 expression in patients with ASO after bare metal stent implantation is related to the occurrence of ISR,and has certain predictive and evaluated value on the occurrence of ISR.
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