Diagnostic Value of High-Frequency Ultrasound Combined with Serum LAG-3 and FGFR-4 in Thyroid Cancer
Objective:To investigate the expression of serum lymphocyte activation gene 3(LAG-3)and fibroblast growth factor receptor 4(FGFR-4)in thyroid cancer(TC),and the diagnostic value of them combined with high-frequency ultrasound for TC.Methods:A total of 203 patients with thyroid lesions admit-ted to our hospital from December 2020 to December 2023 were enrolled as the study subjects.Based on the pathological examination results,they were separated into TC patients as the TC group(n=108)and benign thyroid lesions patients as the non-TC group(n=95).ELISA method was applied to determine the expression levels of serum LAG-3 and FGFR-4.ROC curve was plotted to analyze the diagnostic efficacy of serum LAG-3 and FGFR-4 for TC.Four grid table method was applied to analyze the diagnostic efficacy of high-fre-quency ultrasound combined with serum LAG-3 and FGFR-4 levels for TC.Results:Compared with undiffer-entiated thyroid carcinoma,the serum LAG-3 level of papillary,follicular,and medullary thyroid carcinoma was significantly increased,and the serum FGFR-4 level was significantly decreased(P<0.05).Compared with the non-TC group,the serum LAG-3 level in the TC group was reduced,and the serum FGFR-4 level was increased(P<0.05).The levels of PSV and RI in the TC group were higher than those in the non-TC group(P<0.05).The accuracy,sensitivity,and specificity of high-frequency ultrasound combined with ser-um LAG-3 and FGFR-4 in diagnosing TC were 86.70％,96.30％,and 75.79％,respectively.Among them,the sensitivity of the three combined diagnoses was higher than that of high-frequency ultrasound,ser-um LAG-3,and FGFR-4 individual diagnoses(P<0.05).Conclusion:The serum LAG-3 level in TC pa-tients is reduced,while the serum FGFR-4 level is increased.High-frequency ultrasound combined with ser-um LAG-3 and FGFR-4 has higher diagnostic efficacy for TC.
Lymphocyte activation gene-3Fibroblast growth factor receptor 4High frequency color ultrasoundThyroid cancerDiagnosis
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