术前白细胞衍生性指标对肝癌介入术后早期复发的预测价值研究
A Study on the Predictive Value of Preoperative Leukocyte Derivativeness Index for Early Recurrence after Hepatocellular Carcinoma Intervention
陈恕 1吉九威 1刘晓宇 1冯立1
作者信息
- 1. 北京大学肿瘤医院内蒙古医院,内蒙古 呼和浩特 010020
- 折叠
摘要
目的:分析术前白细胞衍生性指标对肝癌介入术后早期复发的预测价值.方法:将 2020年1 月至 2023 年 1 月于本院行肝癌介入术的 216 例患者纳为研究对象,术后对其进行为期 1 年的随访,依据其复发情况将其分为复发组(n=110)和未复发组(n=106).所有研究对象均在术前测定白细胞衍生指标,包括中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)和淋巴细胞与单核细胞比值(LMR),以受试者工作特征曲线(ROC)分析术前NLR、PLR及LMR水平对肝癌介入术后早期复发的预测价值.结果:复发组的术前NLR、PLR水平高于未复发组,LMR水平低于未复发组(P<0.05).ROC曲线分析结果显示,术前NLR、PLR及 LMR 水平联合预测肝癌介入术后早期复发的曲线下面积(AUC)为0.958,灵敏度为82.73%,特异性为 95.28%,联合预测效能优于各指标单独预测(P<0.05).结论:术前白细胞衍生性指标与肝癌介入术后早期复发密切相关,术前测定 NLR、PLR 及 LMR 水平可预测肝癌介入术后的早期复发情况,为指导临床治疗提供一定的参考依据.
Abstract
Objective:To analyze the predictive value of preoperative leukocyte-derived indicators on early recurrence of liver cancer after interventional surgery.Methods:Totally 216 patients who underwent in-terventional surgery for liver cancer in the hospital were included in the study from January 2020 to January 2023.They were followed up for 1 year after surgery and were divided into a recurrence group(n=110)and a non-recurrence group(n=106)according to the recurrence status.Leukocyte-derived indicators of all study subjects were measured before surgery,including neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),and lymphocyte-to-monocyte ratio(LMR).Subject operating characteristic curve(ROC)was performed to analyze the predictive value of preoperative levels of NLR,PLR,and LMR on early recurrence after interventional surgery for liver cancer.Results:The preoperative NLR and PLR levels in the recurrence group were higher than those in the non-recurrence group while the LMR level was lower than in the non-recurrence group(P<0.05).ROC curve analysis results showed that the area under the curve(AUC)of a combination of preoperative NLR,PLR,and LMR in predicting early recurrence after liver canc-er interventional surgery was 0.958,with a sensitivity of 82.73%and a specificity of 95.28%.The efficiency of combined prediction was better than that of each indicator(P<0.05).Conclusion:Preoperative leukocyte-derived indicators are closely related to early recurrence of liver cancer after interventional surgery.Preopera-tive measurement of NLR,PLR,and LMR levels can predict early recurrence after liver cancer interventional surgery,and provide a certain reference basis for guiding clinical treatment.
关键词
肝癌介入术/中性粒细胞与淋巴细胞比值/血小板与淋巴细胞比值/淋巴细胞与单核细胞比值Key words
Hepatocellular carcinoma intervention/Neutrophil-to-lymphocyte ratio/Platelet-to-lymphocyte ratio/Lymphocyte-to-monocyte ratio引用本文复制引用
基金项目
2022年度自治区卫生健康科技计划项目(202202222)
内蒙古医科大学青年项目(YKD2022QN042)
出版年
2024
国家科技期刊平台
NSTL
万方数据