摘要
目的:探究多层螺旋 CT 联合血清胆碱酯酶(ChE)、α-羟丁酸脱氢酶(α-HBDH)、颗粒蛋白前体(PGRN)对肺结核合并肺癌的诊断价值.方法:选取 2021 年 6 月至 2023 年 6 月本院收治的84 例肺结核患者,其中经过病理检测确诊为肺结核合并肺癌患者36 例即为研究组,单纯肺结核患者 48例为对照组.患者均进行多层螺旋CT 检测.采用酶联免疫吸附试验(ELISA)法检测血清中 ChE、α-HBDH、PGRN表达水平.ROC曲线分析多层螺旋 CT 联合血清 ChE、α-HBDH、PGRN 对肺结核合并肺癌的诊断价值.结果:研究组肿块、胸膜凹陷征、分叶征、胸腔积液、毛刺征、结节影占比显著高于对照组(P<0.05).与对照组相比,研究组患者血清中ChE水平显著降低,α-HBDH、PGRN 水平显著升高(P<0.05).与单独诊断相比,多层螺旋CT联合血清ChE、α-HBDH、PGRN对肺结核合并肺癌诊断的 AUC显著升高(z=3.497,P=0.001;z=4.310,P<0.001;z=3.328,P=0.001;z=4.518,P<0.001).结论:肺结核合并肺癌患者血清 ChE 低表达,α-HBDH、PGRN 高表达,多层螺旋 CT 联合血清 ChE、α-HBDH、PGRN对肺结核合并肺癌具有较高诊断价值.
Abstract
Objective:To explore the diagnostic value of multi-slice spiral CT combined with serum cholinesterase(ChE),α-hydroxybutyrate dehydrogenase(α-HBDH),and progranulin(PGRN)in the di-agnosis of pulmonary tuberculosis combined with lung cancer.Methods:From June 2021 to June 2023,84 patients with pulmonary tuberculosis accepted by our hospital were collected.Among them,36 patients diag-nosed with pulmonary tuberculosis combined with lung cancer through pathological examination were made the test group,and 48 patients with simple pulmonary tuberculosis were made the control group.All patients un-derwent multi-slice spiral CT examination.Enzyme-linked immunosorbent assay(ELISA)was applied to de-tect the expression levels of ChE,α-HBDH,and PGRN in serum.ROC curve was applied to analyze the di-agnostic value of multi-slice spiral CT combined with serum ChE,α-HBDH,and PGRN for pulmonary tuber-culosis combined with lung cancer.Results:The proportions of masses,pleural indentation sign,lobulation sign,pleural effusion,spiculation,and nodular shadow sign in the test group were higher than those in the control group(P<0.05).Compared with the control group,the serum ChE level in the test group was re-duced,while α-HBDH and PGRN levels were increased(P<0.05).Compared with individual diagnosis,the combination of multi-slice spiral CT and serum ChE,α-HBDH,and PGRN had a higher AUC in the di-agnosis of pulmonary tuberculosis combined with lung cancer(z=3.497,P=0.001;z=4.310,P<0.001;z=3.328,P=0.001;z=4.518,P<0.001).Conclusion:Serum ChE expression is low,and the α-HBDH and PGRN expression is high in patients with pulmonary tuberculosis combined with lung cancer.Multi-slice spiral CT combined with serum ChE,α-HBDH,and PGRN has a high diagnostic value for pulmonary tuber-culosis combined with lung cancer.
基金项目
2021年度湖北省教育厅科学研究计划指导性项目(B2021031)
万方数据