Diagnostic Value of Multi-Slice Spiral CT Combined with Serum ChE α-HBDH and PGRN for Pulmonary Tuberculosis Combined with Lung Cancer
Objective:To explore the diagnostic value of multi-slice spiral CT combined with serum cholinesterase(ChE),α-hydroxybutyrate dehydrogenase(α-HBDH),and progranulin(PGRN)in the di-agnosis of pulmonary tuberculosis combined with lung cancer.Methods:From June 2021 to June 2023,84 patients with pulmonary tuberculosis accepted by our hospital were collected.Among them,36 patients diag-nosed with pulmonary tuberculosis combined with lung cancer through pathological examination were made the test group,and 48 patients with simple pulmonary tuberculosis were made the control group.All patients un-derwent multi-slice spiral CT examination.Enzyme-linked immunosorbent assay(ELISA)was applied to de-tect the expression levels of ChE,α-HBDH,and PGRN in serum.ROC curve was applied to analyze the di-agnostic value of multi-slice spiral CT combined with serum ChE,α-HBDH,and PGRN for pulmonary tuber-culosis combined with lung cancer.Results:The proportions of masses,pleural indentation sign,lobulation sign,pleural effusion,spiculation,and nodular shadow sign in the test group were higher than those in the control group(P<0.05).Compared with the control group,the serum ChE level in the test group was re-duced,while α-HBDH and PGRN levels were increased(P<0.05).Compared with individual diagnosis,the combination of multi-slice spiral CT and serum ChE,α-HBDH,and PGRN had a higher AUC in the di-agnosis of pulmonary tuberculosis combined with lung cancer(z=3.497,P=0.001;z=4.310,P<0.001;z=3.328,P=0.001;z=4.518,P<0.001).Conclusion:Serum ChE expression is low,and the α-HBDH and PGRN expression is high in patients with pulmonary tuberculosis combined with lung cancer.Multi-slice spiral CT combined with serum ChE,α-HBDH,and PGRN has a high diagnostic value for pulmonary tuber-culosis combined with lung cancer.
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