Correlation between Serum IL-35 and CCL19 Levels and Immunological Indexes in Children with Systemic Lupus Erythematosus
Objective:To observe the changes of serum interleukin-35(IL-35)and C-C motif chemo-kine ligand 19(CCL19)in children with systemic lupus erythematosus(SLE),and to analyze the association with immunological indexes.Methods:A total of 97 children with SLE in the hospital were included from January 2022 to March 2024,and 97 healthy children were selected for control study during the same time pe-riod.The changes of serum IL-35 and CCL19 levels were observed,and the correlation with immunological indexes[including anti-ds-DNA antibody,immunoglobulin(Ig),complements C3 and C4]was analyzed.Results:Compared with the healthy children,the children with SLE had a significantly lower serum IL-35 level and a significantly higher serum CCL19 level(P<0.05).Compared with the children with inactive SLE,serum levels of IL-35,C3,and C4 in the children with active SLE were significantly lower while serum levels of CCL19,anti-ds-DNA antibody,IgM,IgG,and IgA were significantly higher(P<0.05).Pearson correla-tion analysis showed that the serum level of IL-35 in children with SLE was negatively correlated with the lev-els of anti-ds-DNA antibody,IgM,IgG,and IgA,and was positively correlated with the levels of C3 and C4(P<0.05).Serum CCL19 level was positively correlated with the levels of anti-ds-DNA antibody,IgM,IgG and IgA,and was negatively correlated with the levels of C3 and C4 in children with SLE(r=-0.314,-0.203,-0.301,-0.201,0.318,0.383,P<0.05).Linear regression analysis suggested that anti-ds-DNA antibody had a negative impact on IL-35 level in children with SLE(r=0.272,0.209,0.362,0.202,-0.219,-0.391,P<0.05)while C3 had a positive impact on IL-35 level(P<0.05).IgG in children with SLE had a positive impact on CCL19 level(P<0.05).Conclusion:The abnormal changes of serum IL-35 and CCL19 levels in children with SLE are correlated with the levels of anti-ds-DNA antibody,IgM,IgG and IgA.There is a certain influence relationship between anti-ds-DNA antibody,C3 and IL-35,IgG and CCL19.
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