Impact of Low-Dose Chemotherapy Combined with Postoperative Radiotherapy on the Prognosis of Stage Ⅲ Ⅳ Oral Cancer Patients and Analysis of Related Factors
Impact of Low-Dose Chemotherapy Combined with Postoperative Radiotherapy on the Prognosis of Stage Ⅲ Ⅳ Oral Cancer Patients and Analysis of Related Factors
Objective:To observe the impact of low-dose chemotherapy combined with postoperative ra-diotherapy on the prognosis of patients with stage Ⅲ-Ⅳ oral cancer and to analyze the factors affecting progno-sis.Methods:A total of 90 patients with stage Ⅲ～Ⅳ oral cancer,treated at our hospital between January 2019 and May 2022,were selected and randomly divided into two groups:the control group(n=45)received postoperative radiotherapy,and the combined group(n=45)received low-dose preoperative chemotherapy combined with postoperative radiotherapy.Clinical efficacy and the 2-year recurrence rates were compared be-tween the two groups.Based on the patients'2-year postoperative recurrence status,they were divided into the recurrence group and the non-recurrence group,and a multivariate logistic regression analysis was conduc-ted to identify factors influencing prognosis.Results:The disease control rate(DCR)of the combined group was significantly higher than that of the control group(P<0.05).After a 2-year follow-up,3 patients from the combined group and 4 from the control group were lost to follow-up.Among the 83 patients who completed follow-up,39 experienced recurrence,with an overall recurrence rate of 46.99%(39/83).The recurrence rate in the combined group was 40.48%(17/42),compared to 53.66%(22/41)in the control group,with no statistically significant difference between the two groups(P>0.05).Significant differences were observed between the recurrence and non-recurrence groups in terms of pN stage,pathological differentiation,lymph node ratio,and nerve invasion(P<0.05).Multivariate analysis showed that pN stage,lymph node ratio,and nerve invasion were influencing factors for postoperative recurrence in patients with stage Ⅲ-Ⅳ oral cancer(P<0.05).Conclusion:Low-dose chemotherapy combined with postoperative radiotherapy improves clinical ef-ficacy in patients with stage Ⅲ-Ⅳ oral cancer,but has no significant advantage in improving prognosis.Prog-nosis-related factors include pN stage,lymph node ratio,and nerve invasion.
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