河北医学2024,Vol.30Issue(10) :1722-1727.DOI:10.3969/j.issn.1006-6233.2024.10.026

感染所致急性肾损伤老年患者NEU/ALB血流动力学免疫球蛋白水平与肾功能转归的关系研究

Relationship between NEU/ALB Hemodynamics,Immunoglobulins and Renal Function Outcome in Elderly Patients with Infection-Induced Acute Kidney Injury

谢娟 倪刚 潘亚超 王羊洋
河北医学2024,Vol.30Issue(10) :1722-1727.DOI:10.3969/j.issn.1006-6233.2024.10.026

感染所致急性肾损伤老年患者NEU/ALB血流动力学免疫球蛋白水平与肾功能转归的关系研究

Relationship between NEU/ALB Hemodynamics,Immunoglobulins and Renal Function Outcome in Elderly Patients with Infection-Induced Acute Kidney Injury

谢娟 1倪刚 1潘亚超 1王羊洋1
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作者信息

  • 1. 安徽省合肥市第一人民医院,安徽 合肥 230000
  • 折叠

摘要

目的:探讨感染所致急性肾损伤老年患者中性粒细胞(NEU)/白蛋白(ALB)、血流动力学、免疫球蛋白水平与肾功能转归的关系.方法:选取我院 2021 年 1 月至 2023 年 12 月收治的 117 例感染所致急性肾损伤老年患者为研究对象,入院时均进行NEU、ALB、血流动力学和免疫球蛋白检测,患者采用综合对症治疗,根据其肾功能转归情况将患者分为转归良好组和转归不良组,对比两组 NEU/ALB、血流动力学、免疫球蛋白水平,采用多因素Logistic回归分析感染所致急性肾损伤老年患者肾功能转归的影响因素.结果:转归良好组性别、年龄、体质指数(BMI)、尿蛋白与转归不良组比较差异无统计学意义(P>0.05),血清肌酐水平低于转归不良组(P<0.05).转归良好组 NEU、NEU/ALB 水平均低于转归不良组(P<0.05),ALB 和IgG、IgM水平均高于转归不良组(P<0.05),MAP、CI均大于转归不良组(P<0.05),HR、IgA水平与转归不良组比较差异无统计学意义(P>0.05).多因素Logistic回归分析,结果显示NEU/ALB、MAP、CI、IgG均是感染所致急性肾损伤老年患者肾功能转归的影响因素(P<0.05).结论:感染所致急性肾损伤老年患者NEU/ALB、血流动力学、免疫球蛋白水平与其肾功能转归存在相关性,检测上述指标有利于评估患者肾功能转归情况.

Abstract

Objective:To investigate the relationship of neutrophil(NEU)/albumin(ALB),hemody-namics and immunoglobulins levels with renal function outcome in elderly patients with infection-induced a-cute kidney injury(AKI).Methods:Totally 117 elderly patients with infection-induced AKI in the hospital were selected from January 2021 to December 2023 as the research subjects.NEU,ALB,hemodynamics and immunoglobulin were detected at admission.The patients were treated with comprehensive symptomatic treat-ment and were divided into good outcome group and poor outcome group according to the outcome of renal function.The levels of NEU/ALB,hemodynamics and immunoglobulins were compared between groups.Mul-tivariate Logistic regression analysis was used to analyze the influencing factors of renal function outcome in elderly patients with infection-induced AKI.Results:There were no statistical differences in gender,age,body mass index(BMI)and urinary protein between the good outcome group and the poor outcome group(P>0.05),but serum creatinine level was lower than that in the poor outcome group(P<0.05).NEU and NEU/ALB in the good outcome group were lower than those in the poor outcome group(P<0.05)while ALB,IgG and IgM levels were higher(P<0.05),and MAP and CI were higher than those in the poor outcome group(P<0.05),but the HR and IgA were not statistically different compared with those in the poor outcome group(P>0.05).Multivariate Logistic regression analysis showed that NEU/ALB,MAP,CI and IgG were influencing factors of renal function outcome in elderly patients with infection-induced AKI(P<0.05).Con-clusion:The NEU/ALB,hemodynamics and immunoglobulins levels are correlated with renal function out-come in elderly patients with infection-induced acute kidney injury.The detection of the above indicators is helpful to evaluate the renal function outcome of patients.

关键词

急性肾损伤/感染/中性粒细胞/清蛋白/血流动力学/免疫球蛋白

Key words

Acute kidney injury/Infection/Neutrophil/Albumin/Hemodynamics/Immu-noglobulins

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基金项目

安徽省健康发展战略研究中心资政项目(2023szk001)

出版年

2024
河北医学
河北省医学会

河北医学

CSTPCD
影响因子:1.915
ISSN:1006-6233
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