Effect of Polyene Phosphatidylcholine Injection Combined with Adenosylmethionine Butanedisulfonate on Liver Function,Albumin,and Coagulation Indicators in Patients with Liver Failure
Objective:To investigate the effects of polyene phosphatidylcholine injection combined with adenosylmethionine butanedisulfonate on liver function,albumin,and coagulation indicators in patients with liver failure.Methods:A total of 107 patients with liver failure treated at The First Affiliated Hospital of An-hui Medical University from December 2021 to December 2023 were selected and randomly divided into a con-trol group(n=53,treated with polyene phosphatidylcholine injection)and a combined group(n=54,treated with polyene phosphatidylcholine injection combined with adenosylmethionine butanedisulfonate).The thera-peutic effects,liver function,protein-related indicators,coagulation function,and complications of liver fail-ure were compared between the two groups.Results:The total effective rate in the combined group(94.44%)was higher than in the control group(81.13%),with a statistically significant difference(P<0.05).After 4 weeks of treatment,the differences in alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBIL)levels before and after treatment were greater in the combined group[(204.07±22.85)U/L,(151.45±30.16)U/L,(212.10±26.64)μmoL/L]compared to the control group[(189.23±24.70)U/L,(123.03±29.48)U/L,(196.59±23.20)μmoL/L〛,with statistical signif-icance(P<0.05).The combined group also showed significantly higher improvements in serum total protein(TP),albumin(ALB),and prealbumin(PA)levels[(7.41±2.26)g/L,(8.53±2.08)g/L,(55.24±10.72)mg/L]compared to the control group[(2.64±1.69)g/L,(4.56±1.75)g/L,(36.18±11.82)mg/L](P<0.05).Additionally,fibrinogen(FIB),prothrombin activity(PTA),and D-dimer(D-D)im-provements in the combined group[(0.55±0.17)g/L,(24.89±3.92)%,(1.21±0.44)mg/L]were grea-ter than those in the control group[(0.34±0.20)g/L,(18.33±4.06)%,(1.02±0.35)mg/L](P<0.05).The incidence of complications of liver failure was not significantly different between the two groups(P>0.05).Conclusion:The combination of polyene phosphatidylcholine injection and adenosylmethionine bu-tanedisulfonate improves liver and coagulation function in patients with liver failure.The combined treatment is more effective than monotherapy.
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