Evaluation of the Efficacy and Safety of Budesonide Combined with Interferon α2b Nebulization in the Treatment of Infantile Bronchopneumonia
Objective:To evaluate the efficacy and safety of budesonide combined with interferon α2b nebulization in the treatment of infantile bronchopneumonia.Methods:A total of 102 infants and young chil-dren with bronchopneumonia admitted to our hospital from 2021.09 to 2023.07 were enrolled.According to the random number table method,they were divided into the conventional group(conventional symptomatic treatment+budesonide atomization inhalation)and combined group(combined with interferon α2b atomiza-tion inhalation on the basis of the conventional group),with 51 cases in each group.The clinical efficacy,im-provement time of symptoms(cough,wheezing,wheezing rale,three concave signs),blood gas indexes[oxy-genation index,partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2)],T lympho-cyte indicators(CD3+CD4+,CD3+CD8+,CD3-CD19+)and peripheral blood inflammation indexes[Interleu-kin-6(IL-6),tumor necrosis factor α(TNF-α),C-reactive protein(CRP)]before and after treatment were compared between the two groups,and the adverse drug reactions were compared.Results:The total ef-fective rate of the combined group(98.40%)was higher than that of the conventional group(86.27%)((P<0.05).The improvement time of symptoms in the combined group was shorter than that in the conventional group(P<0.05).Before treatment,there were no statistical differences in serum indexes between groups(P>0.05).After treatment,the oxygenation index and PaO2 in the two groups were increased(P<0.05)while the PaCO2 was decreased(P<0.05),and the differences before and after treatment in the combined group were higher(P<0.05).No statistical differences were shown in T lymphocyte indexes between groups before treatment(P>0.05).After treatment,CD3+CD4+and CD3+CD8+in both groups of children were risen(P<0.05)while CD3-CD19++was declined(P<0.05),and the differences before and after treatment were higher in the combined group than those in the conventional group(P<0.05).Before treatment,there were no statistical differences in peripheral blood inflammation indexes between groups(P>0.05).After treatment,the peripheral blood inflammatory indexes(IL-6,TNF-α,CRP)in the two groups were significantly de-creased(P<0.05),and the differences before and after treatment in the combined group were higher than those in the conventional group(P<0.05).There was no statistical significance in the total incidence rate of adverse drug reactions between the combined group(7.84%)and the conventional group(5.88%)(P>0.05).Conclusion:Budesonide combined with interferon α2 b atomization inhalation is beneficial to improve the clinical symptoms,lung function and immune inflammatory response of infants and young children with bronchopneumonia,and improve the efficacy,with high safety.
万方数据
维普
