Association of TNF-α Gene Polymorphisms with Pulmonary Infection After Heart Valve Replacement
Objective:To investigate the correlation between lung infection and tumor necrosis factor-al-pha(TNF-α)gene polymorphism after heart valve replacement(HVR)surgery.Methods:A total of 80 pa-tients with HVR in Nanjing Drum Tower Hospital from January 2020 to December 2023 were retrospectively se-lected,and they were divided into lung infection group(30 cases)and non-lung infection group(50 cases)according to the presence or absence of postoperative lung infection.Results:A total of 43 strains of patho-genic bacteria were detected in 30 patients with pulmonary infection,mainly gram-negative bacteria(62.79%),with Escherichia coli(20.93%).Followed by Gram-positive bacteria(25.58%),with Staphylococ-cus aureus(13.95%).Finally,fungi accounted for 11.63%,with Candida alba(9.30%).The lung infec-tion group had significantly higher the proportion of age,hyperlipidemia,diabetes and cerebral infarction,sig-nificantly more the amount of intraoperative blood loss,and significantly longer the duration of ventilator use,cardiopulmonary bypass and ICU stay compared to the non-lung infection group(all P<0.05).The lung in-fection group presented significantly lower the proportion of the left ventricular ejection fraction,GG genotype frequency of TNF-α gene rs1800629,and G allele frequency and significantly higher the proportion of GA,AA and A relative to the non-lung infection group(all P<0.05).The influencing factors of postoperative pul-monary infection included ICU stay time,extracorporeal circulation time,TNF-α gene rs1800629 site AA(P<0.05).Conclusion:There is a significant correlation between lung infection after HVR and TNF-α gene polymorphism,and the latter is a predisposing factor for the former.
万方数据
维普
