Effects of LYR Ferritin and S-LDH on the Prognosis of Children with Newly Diagnosed Acute Promyelocytic Leukemia and its Early Warning Significance
Objective:To investigate the effects of circulating lymphocyte ratio(LYR),ferritin and ser-um-lactate dehydrogenase(S-LDH)on the prognosis of children with newly diagnosed acute promyelocytic leukemia(APL)and its early warning significance.Methods:A total of 89 children with newly diagnosed APL admitted to our hospital from January 2018 to December 2023 were divided into complete response(CR)group and non-CR group according to the prognosis after treatment.Clinical data,levels of LYR,ferritin and S-LDH were compared between the two groups,and the net correlation between LYR,ferritin and S-LDH with disease outcome was analyzed.Receiver operating characteristic(ROC)curves were conducted to ana-lyze the value of LYR,ferritin and S-LDH in predicting the disease outcome,and evaluate the effects of dif-ferent expression levels of LYR,ferritin and S-LDH on the disease outcome.Results:The LYR in non-CR group was significantly lower than that in CR group,and the ferritin and S-LDH were significantly higher than those in CR group(P<0.05).LYR,ferritin and S-LDH were significantly correlated with the disease out-come(P<0.05),and the net correlation coefficients of LYR,ferritin and S-LDH were-0.825,0.860 and 0.812,respectively.The optimal cut-off values of LYR,ferritin and S-LDH were 34.12,261.22 and 511.39,respectively,and the area under the ROC curve(AUC)was 0.779,0.802 and 0.797,respectively.Odds ratio(OR)for risk analysis showed that the risk of non-CR in patients with high LYR,ferritin and S-LDH expression was 0.120,12.783 and 9.579 times higher than that in patients with low expression,respec-tively.The AUC of combined prediction of LYR,ferritin,and S-LDH for non-CR was 0.916(95%CI:0.838-0.964),with the sensitivity of 88.89%,and the specificity of 83.10%.Conclusion:The levels of LYR,ferritin and S-LDH are closely related to the disease outcome of APL patients,which provide a refer-ence for clinical evaluation and prediction in early APL patients,formulating corresponding intervention pro-grams to improve the prognosis.
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