Correlation between NLR IL-6 CRP with the Prognosis of Patients with Pooled Severe Pneumonia and Septic Shock
Objective:To analyze the correlation neutrophil to lymphocyte ratio(NLR),interleukin-6(IL-6)and C-reactive protein(CRP)with the prognosis of patients with pooled severe pneumonia(SP)and septic shock(SS).Methods:Ninety-eight patients pooled SP and SS admitted to our hospital from January 2019 to December 2023 were enrolled.The key observation was the correlation of the changes in levels of NLR,IL-6,and CRP with the prognosis of patients.Results:The levels of NLR,IL-6 and CRP in the poor prognosis group were significantly higher than those in the good prognosis group(P<0.05).Pearson correla-tion analysis revealed that the levels of NLR,IL-6 and CRP were positively correlated with shock index(r=0.412,0.381,0.354,P<0.05).Univariate analysis showed that shock index,SOFA score and malnutrition were associated with poor prognosis(P<0.05).Multivariate Logistic regression found that NLR,IL-6,CRP,shock index,SOFA score and malnutrition were risk factors for poor prognosis(P<0.05).ROC analysis showed that the AUCs of NLR,IL-6 and CRP in evaluating the poor prognosis of patients were 0.757,0.743 and 0.708 respectively.The AUC of NLR+IL-6+CRP was the highest(0.841),and the sensitivity and spe-cificity were 0.774 and 0.836 respectively.The AUC,sensitivity and specificity of combined assessment of NLR,IL-6,CRP,shock index,SOFA score and malnutrition were 0.906,0.871 and 0.806 respectively.Conclusion:NLR,IL-6 and CRP were abnormally elevated in patients with severe pneumonia combined with septic shock.These three indexes combined with shock index,SOFA score and nutritional status had a high value in evaluating the prognosis of patients.
Severe pneumoniaSeptic shockPrognosisNeutrophil to lymphocyte ratioIn-terleukin-6C-reactive protein
万方数据
维普
