Relationship between β-hCG Levels TNF-α/IL-10 Ratio and Adverse Pregnancy Outcomes in Pregnant Women with Gestational Diabetes Mellitus
Objective:To observe the changes of β-human chorionic gonadotropin(β-hCG)and tumor necrosis factor-α(TNF-α)/interleukin-10(IL-10)ratio in patients with gestational diabetes mellitus(GDM),and to analyze the relationship with adverse pregnancy outcomes.Methods:A total of 102 GDM pa-tients admitted to our hospital from January 2020 to January 2023 were included.The serum levels of β-hCG and the TNF-α/IL-10 ratio were detected,and their association with adverse pregnancy outcomes was ana-lyzed.Results:Serum β-hCG and TNF-α/IL-10 ratio of pregnant women with adverse pregnancy outcomes were significantly higher than those of pregnant women with normal pregnancy outcomes(P<0.05).Univari-ate analysis showed that history of adverse pregnancy,bacterial vaginosis,age and HbA1c were associated with adverse pregnancy outcomes in GDM patients(P<0.05).Logistic regression analysis indicated that ad-verse pregnancy history,age,HbA1c,β-hCG,and TNF-α/IL-10 ratio were risk factors for adverse preg-nancy outcomes in GDM patients(P<0.05).ROC results suggested that the AUCs of serum β-hCG and TNF-α/IL-10 in evaluating adverse pregnancy outcomes in GDM patients were 0.804(95%CI:0.695～0.912)and 0.729(95%CI:0.614～0.844)respectively.The AUC of the combination of the two indicators was 0.867(95%CI:0.787～0.947)in assessing the adverse pregnancy outcomes,and the sensitivity and specificity under the maximum Youden index were 0.786 and 0.811,respectively.Conclusion:Abnormal increases in serum β-hCG and the TNF-α/IL-10 ratio in GDM pregnant women are associated with adverse pregnancy outcomes,and their combined assessment has a high evaluation value for adverse pregnancy outcomes.
万方数据
维普
