Correlation between Serum 25OHD FABP4 and sVEGFR-1 with Disease Progression in Hypertensive Disorder of Pregnancy
Objective:To investigate correlation between serum levels of 25-hydroxyvitamin D(25OHD),fatty acid binding protein 4(FABP4),and soluble vascular endothelial growth factor receptor-1(sVEGFR-1)with disease progression of pregnant women with hypertensive disorders of pregnancy(HDP).Methods:From October 2022 to October 2023,120 pregnant women with HDP in People's Hospital of Xin-jiang Uygur Autonomous Region(study group)and 120 normal pregnant women(control group)were includ-ed.The patients in the study group were assigned into the gestational hypertension(GH)subgroup(n=79)and the pre-eclampsia(PE)subgroup(n=41)according to the disease progression.At admission,the lev-els of serum 25OHD,FABP4,and sVEGFR-1 were compared between the study group and the control group,and the levels of serum 25OHD,FABP4,and sVEGFR-1 and the incidence of adverse pregnancy outcome were compared between the two subgroups.The correlation between the levels of serum 25OHD,FABP4,and sVEGFR-1 at admission with the progression of GH to PE was assessed.The levels of serum 25OHD,FABP4,and sVEGFR-1 at admission were compared among patients with different pregnancy outcomes,and the values of the indexes in evaluating the progression of GH to PE and predicting adverse pregnancy outcomes were analyzed.Results:At admission,the study group had significantly lower serum 25OHD level,and high-er levels of FABP4 and sVEGFR-1 than the control group(all P<0.05).PE subgroup had significantly lower serum 25OHD level and the incidence of adverse pregnancy outcomes,and higher levels of FABP4 and sVEG-FR-1 than the GH subgroup(all P<0.05).Low serum 25OHD levels and high serum FABP4 and sVEGFR-1 levels at admission were independent risk factors for the progression of GH to PE(P<0.05).The total in-cidence of adverse pregnancy outcomes in the study group was 35.83%(43/120).At admission,the patients with poor pregnancy outcomes presented significantly lower serum 25OHD level,and higher levels of FABP4 and sVEGFR-1 than those with good pregnancy outcomes(P<0.05);the area under the curve(AUC)of the combined indicator in evaluating the progression of GH to PE at admission was significantly higher than that of 25OHD,FABP4,and sVEGFR-1 alone(0.937 vs 0.793,0.813,0.835;P<0.05);the AUC of the com-bined indicator in predicting adverse pregnancy outcomes of HDP patients was significantly higher than that of 25OHD,FABP4,and sVEGFR-1 alone(0.930 vs 0.810,0.757,0.772;P<0.05).Conclusion:The de-creased serum 25OHD level and the increased serum FABP4 and sVEGFR-1 levels in HDP patients are inde-pendent risk factors for the progression of GH to PE.They have certain clinical value in evaluating the pro-gression of GH to PE and predicting the risk of adverse pregnancy outcomes.
Hypertensive disorder of pregnancyPre-eclampsia25-hydroxyvitamin DFatty acid binding protein 4Soluble vascular endothelial growth factor receptor-1
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