基于脑肠轴探究缺血性脑卒中与肠道菌群免疫的研究进展
Developments on exploring the immune correlation between ischaemic stroke and intestinal flora based on brain-gut axis
徐玉洁 1高娟 2王井辉 1任涵 3王子文 2耿硕4
作者信息
- 1. 承德医学院研究生学院, 河北 承德 067000
- 2. 保定市第一中心医院神经内科, 河北 保定 071000
- 3. 河北医科大学研究生学院, 河北 石家庄 050000
- 4. 保定市第一中心医院内分泌实验室, 河北 保定 071000
- 折叠
摘要
人体肠道内定居着大量的微生物群,他们参与机体免疫稳态的调节,并与缺血性脑卒中的发生发展密切相关.脑肠轴的发现将肠道与大脑联系在一起,在人类的健康与疾病过程中发挥重要作用.现综述脑肠轴的调节机制、卒中后肠道菌群及其代谢物的调节以及基于脑肠轴对缺血性脑卒中后的大脑和肠道免疫反应的可能机制.这些研究为探索卒中后肠道和大脑免疫治疗的新方向和改善脑卒中预后提供了重要意义.
Abstract
It has been shown that the human gut is settled with a large microbiota,which is involved in the regu-lation of the body's immune homeostasis and is closely related to the development of ischaemic stroke.The dis-covery of the microbial-gut-brain axis links the gut to the brain and plays an important role in human health and disease processes.This paper reviews the regulatory mechanisms of the microbial-gut-brain axis,the modulation of gut flora and its metabolites after stroke,and the possible mechanisms of the brain-gut axis based on brain and gut immune responses after ischaemic stroke.These studies provide important implications for exploring new di-rections of gut and brain immunotherapy after stroke and improving stroke prognosis.
关键词
缺血性脑卒中/肠道菌群/脑肠轴/免疫Key words
ischaemic stroke/gut flora/microbe-gut-brain axis/immunity引用本文复制引用
出版年
2024
NETL
NSTL
万方数据