Advances in molecular mechanisms of resistance to platinum chemotherapy in ovarian cancer
Platinum drugs are one of the most effective chemotherapy drugs for ovarian cancer,and although the initial response to platinum chemotherapy is as high as 80%,resistance is common.In most advanced patients,eventual relapse and death are caused by acquired resistance.Chemotherapy resistance of ovarian cancer is a major obstacle affecting its therapeutic effect.However,the cause of chemotherapy resistance is unclear and the mechanism is complex,which is a difficult and hot point in clinical and scientific research.Therefore,the study of drug resistance mechanism of ovarian cancer will provide a basis for the exploration and development of chem-otherapy for ovarian cancer.This article reviews the molecular mechanism of platinum resistance in ovarian cancer.
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