Platinum drugs are one of the most effective chemotherapy drugs for ovarian cancer,and although the initial response to platinum chemotherapy is as high as 80%,resistance is common.In most advanced patients,eventual relapse and death are caused by acquired resistance.Chemotherapy resistance of ovarian cancer is a major obstacle affecting its therapeutic effect.However,the cause of chemotherapy resistance is unclear and the mechanism is complex,which is a difficult and hot point in clinical and scientific research.Therefore,the study of drug resistance mechanism of ovarian cancer will provide a basis for the exploration and development of chem-otherapy for ovarian cancer.This article reviews the molecular mechanism of platinum resistance in ovarian cancer.
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