首页|身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型不宁腿综合征的临床观察

身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型不宁腿综合征的临床观察

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目的 观察身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型不宁腿综合征(RLS)患者的临床疗效.方法 将50 名痰瘀痹阻型RLS患者按照随机数字表法分为2 组,对照组25 例予盐酸普拉克索片治疗,治疗组 25 例在对照组基础上联合身痛逐瘀汤加味治疗.2 组均治疗1 周为1 个疗程,治疗 2 个疗程后统计疗效,比较 2 组治疗前后国际RLS严重程度评分量表(IRLS)评分、匹兹堡睡眠质量指数量表(PSQI)评分及中医症状评分变化情况.结果 治疗组总有效率92.00%(23/25),对照组总有效率60.00%(15/25),治疗组总有效率高于对照组(P＜0.05).与本组治疗前比较,2 组治疗后IRLS评分、PSQI评分及中医症状评分均降低(P＜0.05),且治疗组治疗后IRLS评分、PSQI评分及中医症状评分均低于对照组(P＜0.05).结论 身痛逐瘀汤加味联合盐酸普拉克索片治疗痰瘀痹阻型RLS疗效确切,可有效改善患者临床症状及中医症状,改善患者睡眠质量,操作简便,临床疗效显著,安全性良好.
Clinical efficacy of modified Shentong Zhuyu Decoction combined with pramipexole on patients with restless legs syn-drome of phlegm blood stasis blocking
Objective To observe the clinical efficacy of modified Shentong Zhuyu Decoction combined with pramipexole(PMX)on patients with restless legs syndrome(RLS)of phlegm blood stasis blocking.Methods A total of 50 RLS patients(phlegm blood stasis blocking)were randomly assigned into the treatment group(n =25)and the control group(n =25).All patients were managed by PMX,and those in the treatment group were additionally treated with modified Shentong Zhuyu Decoc-tion.The treatment continued for 2 courses(1 course for 1 week),the aim was to compare International Restless Legs Syndrome Severity Scale(IRLS),Pittsburgh Sleep Quality Index(PSQI),traditional Chinese medicine(TCM)symptom score.The cura-tive effect was assessed.Results The overall effective rate in the treatment group was better than that in the control group(92.00%[23/25]vs 60.00%[15/25],[P＜0.05],respectively).After treatment,IRLS,PSQI,TCM symptom scores in the both groups were significantly decreased(P＜0.05),which decreased notably in the treatment group(P＜0.05).Conclu-sion For RLS patients(phlegm blood stasis blocking),modified Shentong Zhuyu Decoction combined with PMX has significant and definite clinical efficacy,which can effectively improve clinical and TCM symptoms,sleep quality,it is easy to operate,and with good safety.

Restless legs syndromePramipexoleShen-tong Zhuyu DecoctionPhlegm blood stasis blockingIntegrated traditional Chinese and Western medicine therapy

杜青、宁倩、徐栋、李鑫、顾宝东、王英超、马先军、赵晓慧

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江苏省连云港市中医院脑病科,江苏 连云港 222000

南京医科大学康达学院附属中医临床医学部,江苏 连云港 222000

江苏省连云港市中医院检验科,江苏 连云港 222000

不宁腿综合征 普拉克索 身痛逐瘀汤 痰瘀痹阻 中西医结合疗法

江苏省老年健康科研项目—临床技术应用研究项目带头人连云港市中医药科技发展计划项目连云港市中医药管理局科技项目南京医科大学康达学院科研发展基金项目

LR2021027YB202205LZYYB202308KD2021KYJJZD089

2024

10.3969/j.issn.1002-2619.2024.01.006

河北中医
河北省医学情报研究所,河北省中医药学会

河北中医

CSTPCD
影响因子：0.951
ISSN：1002-2619
年,卷(期)：2024.46(1)
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