Effects of Huayu Tongluo Formula combined with docetaxel plus cisplatin chemotherapy regimen on non-small cell lung cancer
Objective To explore the effects of Huayu Tongluo Formula combined with docetaxel plus cisplatin(DP)chemotherapy regimen in the treatment of non-small cell lung cancer(NSCLC).Methods From April 2019 to October 2021,a total of 128 patients with NSCLC were randomly assigned into the treatment group(n =61)and the control group(n =67).All patients were given DP chemotherapy,and patients in the treatment group were additionally given Huayu Tongluo Formula,the curative effects of the two groups were statistically analyzed after 1 course of treatment.The key observation was traditional Chi-nese medicine(TCM)symptoms(cough and expectoration,cough with blood,shortness of breath and fatigue,chest tightness and chest pain)scores,immune function indexes(T lymphocyte subsets:CD3+,CD4+ and CD8+)and quality of life scores(QOL)(five dimensions of physiology,emotion,function,family/society and additional attention)between the two groups be-fore and after treatment,as well as treatment-emergent adverse events(TEAEs).Results The total effective rate in the treat-ment group was better than that of the control group(81.97%[50/61]vs65.67%[44/67],P<0.05).The difference was not statistically significant in the total incidence of adverse reactions between the treatment group and the control group(14.75%[9/61]vs 16.42%[11/67],[P>0.05],respectively).After treatment,the TCM symptoms scores in the two groups were significantly decreased(P<0.05),and the de-crease in the treatment group was more pronounced(P<0.05).Compared with before treatment,the levels of T lymphocyte sub-sets(CD3+,CD4+ and CD8+)in the treatment group were significantly increased after treatment(P<0.05),and which in the treatment group were significantly higher than the control group(P<0.05).While,there was no significant difference in the levels of T lymphocyte subsets(CD3+,CD4+ and CD8+)in the control group before and after treatment(P>0.05).The QOL scores in the two groups were significantly increased(P<0.05),and the increase in the treatment group was more obvious(P<0.05).Conclusion Huayu Tongluo Formula combined with DP chemotherapy regimen in the treatment of NSCLC is effective,it can significantly improve TCM symptoms,immune function,and quality of life,and it is safe and reliable.
Non-small cell lung cancerDocetaxelCisplatinChemotherapyTraditional Chinese medicine therapy