Clinical efficacy of Jianpi Yishen Jiangzhuo Formula for diabetic kidney disease and its influence on micro-inflamma-tion status
Objective To observe the clinical efficacy of Jianpi Yishen Jiangzhuo Formula for diabetic kidney disease(DKD)and its influence on micro-inflammation status.Methods From January 2020 to March 2021,a total of 80 DKD pa-tients were randomly assigned into the treatment group(n =40)and the control group(n =40).All patients were managed by routine Western medicine,and those in the treatment group were additionally treated with Jianpi Yishen Jiangzhuo Formula.Treated for 12 weeks,the aim was to compare blood glucose indexes(fasting plasma glucose[FPG],2-h postprandial glucose[2 hPG],glucose hemoglobin[HbA1c]),inflammatory indexes(High-sensitivity C-reactive protein[hs-CRP],interleu-kin8[IL-8],IL-6,tumor necrosis factor alpha[TNF-α]),renal function indexes(serum creatinine[Scr],blood urea nitrogen[BUN],urinary albumin excretion rate[UAER]),tra-ditional Chinese medicine(TCM)symptom score.The curative effect was assessed.Results After treatment,FPG,2 hPG and HbA1 c in the both groups were significantly decreased compared those before treatment(P＜0.05),but with no statistically signif-icant difference between the treatment group and the control group(P＞0.05).After treatment,hs-CRP,IL-8,IL-6,TNF-α in the both groups were significantly decreased(P＜0.05),which decreased notably in the treatment group compared with the control group(P＜0.05).SCr,BUN and UAER in the both groups were significantly decreased(P＜0.05),the reduction in the treatment group was more prevalent compared with the control group(P＜0.05).TCM symptom scores in the both groups were significantly decreased(P＜0.05),the decrease in the treatment group was more common than the control group(P＜0.05).The overall effective rate in the treatment group was better than that in the control group(87.5%[35/40]vs 62.5%[25/40],[P＜0.05],respectively).Conclusion For DKD patients,Jianpi Yishen Jiangzhuo Formula has definite clinical efficacy,which can effectively improve micro-inflammation status,kidney function,TCM symptoms,thereby slowing down dis-ease progression,and with safety and reliability.
Diabetic kidney diseaseTraditional Chinese medicine therapyJianpi YishenMicro-inflammation
万方数据
维普
