Clinical efficacy of Fuzheng Tonglin Powder on recurrent urinary tract infection of spleen-kidney deficiency and damp-heat type
Objective To observe the clinical efficacy of Fuzheng Tonglin Powder on recurrent urinary tract infection(rUTI)of spleen-kidney deficiency and damp-heat type.Methods One hundred and eight rUTI patients(spleen-kidney deficiency and damp-heat type)were randomly assigned to receive Fuzheng Tonglin Powder(traditional Chinese medicine[TCM]group,n =36)or routine Western medicine(Western medicine[WM]group,n =36)or Fuzheng Tonglin Powder + routine Western medicine(combined group,n =36).The three groups were treated for 3 months and followed up for 6 months,aiming to compareurine routine indexes(white blood cell count[WBC],red blood cell count[RBC]),urine bacterial culture indexes,serum inflammatory indexes(tumor necrosis factor alpha[TNF-α],procalcitonin[PCT],interleukin6[IL-6]).The 36-item Short-Form Health Survey(SF-36)scores on day 0 and on month 1 of treatment were recorded,and the cura-tive effect and recurrence rate were assessed.Results The overall effective rate in the combined group was better than that in the TCM group and WM group(91.67%[33/36]vs 72.22%[26/36],66.67%[24/36],[P＜0.05],respectively).After treatment,WBC and RBC in the three groups were significantly decreased(P＜0.05),which in the combined group weremore lower than TCM group and WM group(P＜0.05),and TCM group wasmore lower than WM group(P＜0.05).TNF-α,PCT,and IL-6 levels in the three groups decreased significantly(P＜0.05),which in the combined group were the lowest,followed by TCM group and WM group(all P＜0.05).The SF-36 scores in the three groups increased significantly(P＜0.05),which in the combined group weremore higher than the other two groups(P＜0.05).The recurrent rate of UTIin the combined group was significantly lower than the other two groups(P＜0.05).Conclusion For rUTI patients(spleen-kidney deficiency and damp-heat type),Fuzheng Tonglin Powder has good curative effect,which can significantly improve inflammation level and quality of life,and reduce recurrence rate.
Recurrent urinary tract infectionIntegrated traditional Chinese and Western medicine therapy
万方数据
维普
