Effect of Modified Danzhi Xiaoyao Powder on hyperprolactinemia in schizophrenia patients
Objective To evaluate the effect of modified Danzhi Xiaoyao Powder on hyperprolactinemia in schizophrenia patients.Methods Totally 118 patients with schizophrenia were randomly assigned into a control group(n =62)and a treat-ment group(n =56).All patients were managed by antipsychotics,and the treatment group was treated with modified Danzhi Xi-aoyao Powder,while the control group was treated with placebo,the treatment was performed for 12 weeks for statistical efficacy.Before treatment and after 4 and 12 weeks of treatment,the positive and negative symptom scale(PANSS)scores were performed to evaluate serum prolactin and psychiatric symptoms.The Schizophrenia Quality of Life Scale(SQLS)involving psychosocial,motivation/energy,symptoms/side-effects three subscales was conducted to assess the quality of life.After 12 weeks of treat-ment,the correlation between serum prolactin level and PANSS score and SQLS score in the treatment group was statistically ana-lyzed.Results After treatment,the levels of 4-week and 12-week serum prolactin in the treatment group were significantly de-creased(P＜0.05),and which were significantly lower in the treatment group than the control group(P＜0.05),but there was no significant difference in serum prolactin between the levels of 4-week and 12-week and that before treatment in the control group(P＞0.05).There was no significant difference in PANSS score between the levels of 4-week and 12-week and that be-fore treatment in the both groups(P＞0.05).Compared with before treatment,the each dimension scores and total score of 4-week and 12-week SQLS in the treatment group were significantly decreased(P＜0.05),and the scores in the treatment group were significantly lower than those in the control group(P＜0.05).However,there was no significant difference in the each di-mension scores and total score of 4-week and 12-week SQLS in the control group compared with those before treatment(P＞0.05).Pearson correlation analysis showed that there was a positive correlation between 12-week serum prolactin level and SQSL(symptoms/side-effects)score in the treatment group(r =0.259,P =0.005;r =0.263,P =0.004).Conclusion For schizophrenia patients with hyperprolactinemia,modified Danzhi Xiaoyao Powder has a definite clinical efficacy,which can effectively reduce the serum prolactin level and improve the quality of life.It is considered to be a clinical adjuvant therapy with therapeutic effect.
SchizophreniaHyperprolactinemiaChinese medicine therapyDanzhi Xiaoyao Powder
万方数据
维普
