Objective To evaluate the effect of modified Danzhi Xiaoyao Powder on hyperprolactinemia in schizophrenia patients.Methods Totally 118 patients with schizophrenia were randomly assigned into a control group(n =62)and a treat-ment group(n =56).All patients were managed by antipsychotics,and the treatment group was treated with modified Danzhi Xi-aoyao Powder,while the control group was treated with placebo,the treatment was performed for 12 weeks for statistical efficacy.Before treatment and after 4 and 12 weeks of treatment,the positive and negative symptom scale(PANSS)scores were performed to evaluate serum prolactin and psychiatric symptoms.The Schizophrenia Quality of Life Scale(SQLS)involving psychosocial,motivation/energy,symptoms/side-effects three subscales was conducted to assess the quality of life.After 12 weeks of treat-ment,the correlation between serum prolactin level and PANSS score and SQLS score in the treatment group was statistically ana-lyzed.Results After treatment,the levels of 4-week and 12-week serum prolactin in the treatment group were significantly de-creased(P＜0.05),and which were significantly lower in the treatment group than the control group(P＜0.05),but there was no significant difference in serum prolactin between the levels of 4-week and 12-week and that before treatment in the control group(P＞0.05).There was no significant difference in PANSS score between the levels of 4-week and 12-week and that be-fore treatment in the both groups(P＞0.05).Compared with before treatment,the each dimension scores and total score of 4-week and 12-week SQLS in the treatment group were significantly decreased(P＜0.05),and the scores in the treatment group were significantly lower than those in the control group(P＜0.05).However,there was no significant difference in the each di-mension scores and total score of 4-week and 12-week SQLS in the control group compared with those before treatment(P＞0.05).Pearson correlation analysis showed that there was a positive correlation between 12-week serum prolactin level and SQSL(symptoms/side-effects)score in the treatment group(r =0.259,P =0.005;r =0.263,P =0.004).Conclusion For schizophrenia patients with hyperprolactinemia,modified Danzhi Xiaoyao Powder has a definite clinical efficacy,which can effectively reduce the serum prolactin level and improve the quality of life.It is considered to be a clinical adjuvant therapy with therapeutic effect.
SchizophreniaHyperprolactinemiaChinese medicine therapyDanzhi Xiaoyao Powder
维普
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