Efficacy of modified Fuzheng Yangyin Powder plus concurrent chemoradiotherapy on advanced cervical cancer
Objective To investigate the efficacy of modified Fuzheng Yangyin Powder plus concurrent chemoradiothera-py on advanced cervical cancer.Methods Eighty-six patients with advanced disease were assigned into a control group(n = 43)and a treatment group(n =43)by a random envelope method.All patients were managed concurrent chemoradiotherapy,and patients in the treatment group were additionally given modified Fuzheng Yangyin Powder.The treatment continued 3 courses for statistical efficacy.Before treatment and after 1 and 3 courses of treatment,the tumor-promoting factors including cathepsin D(CatD)mRNA,Ki-67 mRNA,cathepsin L(CatL)mRNA and CyclinD1 mRNA,tumor-suppressing factors including P53 mRNA,P16 mRNA and fragile histidine triad(FHIT)mRNA,and immune function including T lymphocyte subsets:CD3+,CD4+ and CD4+/CD8+,as well as Karnofsky performance status(KPS)were included as comparisons.The incidences of treatment-emergent adverse events and the survival rates of 6-month follow-up were assessed.Results The objective remission rate in the treatment group was comparable to that of the control group(18.60%[8/43]vs13.95%[6/43],P＞0.05).The disease control rate in the treatment group was signif-icantly higher than that of the control group(88.37%[38/43]vs69.77%[30/43],P＜0.05).After1 and3 courses of treatment,the levels of tumor-promoting factors(serum CatD mRNA,Ki-67 mRNA,CatL mRNA and CyclinD1 mRNA)in the treatment group were significantly decreased(P＜0.05),and which in the treatment group were significantly lower than the control group(P＜0.05).There was no significant difference in cancer-promoting factors between1 and3 courses of treatment and before treatment in the control group(P＞0.05).The levels of tumor-suppressing factors(serum P53 mRNA,P16 mRNA and FHIT mRNA)in the treatment group were significantly increased(P＜0.05),and which in the treatment group were signifi-cantly higher than the control group(P＜0.05).There was no significant difference in tumor-suppressing factors between 1 and 3 courses of treatment and before treatment in the control group(P＞0.05).The levels of T lymphocyte subsets(CD3+,CD4+ and CD4+/CD8+)in the treatment group were significantly increased after 1 and 3 courses of treatment(P＜0.05),and which were significantly higher in the treatment group than the control group(P＜0.05).The concurrent T lymphocyte subsets(CD3+,CD4+ and CD4+/CD8+ levels)in the control group were significantly decreased(P＜0.05).There was no significant change in KPS score in the treatment group after 1 and 3 courses of treatment(P＞0.05).The concurrent KPS scores of the control group decreased significantly(P＜0.05).The KPS scores of the treatment group were significantly higher than those of the control group after 1 and 3 courses of treatment(P＜0.05).The incidence of bone marrow suppression in the treatment group was significantly lower than that in the control group(P＜0.05).There was no significant difference in the incidence of gastrointestinal reaction,alopecia,liver injury and kidney injury between the two groups(P＞0.05).There was no significant difference in the survival rate between the treatment group and the control group(97.56%[40/41]vs92.50%[37/40],P＞0.05).Conclusion For patients with advanced cervical cancer,modified Fuzheng Yangyin Powder plus concurrent chemo-radiotherapy can reduce the expression of tumor-promoting factors,elevate the expression of tumor-suppressing factors,im-prove immune function and survival quality,reduce the occurrence of bone marrow suppression.
Cervical cancerRadiation therapyChemotherapyIntegrative medicine therapy
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