Effect of YiqiWenyangHuoxueLishuiFormula on ventricular remodeling and renin-angiotensin-aldosterone system in patients with chronic heart failure of Yang qi deficiency,blood stasis and phlegm syndrome
Objective To investigate the effect of YiqiWenyangHuoxueLishuiFormula on ventricular remodeling ( VR) and renin - angiotensin - aldosterone system (RAAS) in patients with chronic heart failure (CHF)of Yang qi deficiency, blood stasis and phlegm syndrome. Methods A total of 60 CHF patients( Yang qi deficiency, blood stasis and phlegm syndrome) were randomly assigned into treatment group (n = 30) and control group (n = 30). All patients were managed by conventional Western medicine, those in the treatment group were additionally YiqiWenyangHuoxueLishuiFormula. A 4 - week treatment was performed in the both groups, aiming to compare the curative efficacy, traditional Chinese medicine (TCM) syndrome score, VR parameters, heart failure marker levels, RAAS, as well as the incidence of adverse reactions between the two groups before and after treatment. Results The total effective rate in the treatment group was better than that of the control group (93. 33％ [28/30] vs 73. 33 ％ [22/30], P <0. 05). After treatment, the dimensions scores and total scores of TCM syndromes (main symptoms and secondary symptoms) in the two groups were significantly lower ( P < 0. 05),which in the treatment group were significantly lower than those in the control group ( P < 0. 05). The left ventricular end - diastolic diameter ( LVEDD), left ventricular end - systolic diameter (LVESD), interventricular septal thickness ( IVSd) and left ventricular mass index ( LVMI) in the two groups were significantly lower (P <0. 05), and the right ventricular diameter (RVD) and left ventricular ejection fraction (LVEF) were significantly higher (P < 0. 05). The treatment group was superior to the control group for LVEDD, LVESD, IVSd, LVMI and RVD, LVEF (all P <0.05). The levels of cardiac troponin I (cTnI) and N - terminal pro - brain natriuretic peptide (NT - proBNP) in the two groups were significantly lower (P <0.05),which were more pronounced in the treatment group than in the control group(P <0.05). The levels of plasma renin activity (PRA), angiotensinⅡ(AngⅡ) and aldosterone (ALD) in the both groups were significantly lower (P < 0.05), and this decrease was more common in the treatment group (P <0. 05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0. 05). Conclusion For CHF patients(Yang qi deficiency, blood stasis and phlegm syndrome),YiqiWenyangHuoxueLishuiFormula can inhibit the excessive activation of RAAS, reduce myocardial injury and improve VR, which has significant clinical effect and high safety.
Chronic diseasesHeart failureTraditional Chinese medicine therapy
万方数据
维普
