Improvement effect of Kechuan Yifei Bushen Decoction on the symptoms and signs of patients with chronic bronchitis of wind-cold blocked in lung syndrome by regulating the extracellular signal-related kinases/c-Jun N-terminal ki-nase/p38 mitogen-activated p
Objective To observe the improvement effect of Kechuan Yifei Bushen Decoction on the symptoms and signs of patients with chronic bronchitis(CB)of wind-cold blocked in lung syndrome by regulating the extracellular signal-related kinases(ERK)/c-Jun N-terminal kinase(JNK)/p38 mitogen-activated protein kinase(p38MAPK)pathway.Methods A total of 126 CB patients of wind-cold blocked in lung syndrome were randomly assigned into the treatment group(n =63)and the control group(n =63).All patients were managed by conventional Western medicine,and those in the treatment group were additionally treated with Kechuan Yifei Bushen Decoction.The treatment continued for 2 courses(1 course for 7 days),the aim was to compare improvement of symptoms and signs,traditional Chinese medicine(TCM)syndrome score,arterial blood gas anal-ysis index,pulmonary function index,inflammatory factors,pro-tein expression of JNK,extracellular signal-related kinases 1 and 2(ERK1/2),p38,incidence of adverse reactions.The curative effect was assessed.Results The overall effective rate in the treatment group was better than that in the control group(88.89%[56/63]vs73.02%[46/63],[P<0.05],respectively).The remission duration of cough,expectoration,wheezing,moist rales in the treatment group was significantly shorter than that in the control group(P<0.05).After treatment,TCM symptom scores in the both groups were significantly decreased(P<0.05),which decreased notably in the treatment group compared with the control group(P<0.05).Significantly increased par-tial pressure of oxygen[P(O2)],and decreased partial pressure of carbon dioxide[P(CO2)]were detected in the two groups(all P<0.05),and the treatment group was superior to the control group for P(O2)and P(CO2)(all P<0.05).The differ-ence was not statistically significant in oxygen saturation in the arterial blood(SaO2)between groups(P>0.05).The forced vi-tal capacity(FVC),forced expiratory volume in 1 s(FEV1),FEV1/FVC in the both groups were significantly increased(P<0.05),the increase in the treatment group was more common than the control group(P<0.05).The tumor necrosis factor(TNF-),interleukin8(IL-8),matrix metalloproteinase(MMP)-9 in the both groups were significantly decreased(P<0.05),which were significantly lower in the treatment group than in the control group(P<0.05).The protein expression of JNK,phosphorylated JNK(p-JNK),ERK1/2,p-ERK1/2,p38MAPK,p-p38MAPK in the both groups was significantly decreased(P<0.05),the decrease in the treatment group was more prevalent compared with the control group(P<0.05).The difference was not statistically significant in the total incidence of adverse reactions between the treatment group and the con-trol group(66.67%[42/63]vs 65.08%[41/63],[P>0.05],respectively).Conclusion For CB patients of wind-cold blocked in lung syndrome,Kechuan Yifei Bushen Decoction with conventional Western medicine can effectively improve clinical efficacy,shorten remission duration of clinical symptoms,eliminate inflammatory reactions,and improve lung function and arteri-al blood gas index by reducing the expression of ERK/JNK/p38MAPK pathway.
Chronic diseaseBronchitisTraditional Chinese medicine therapy
万方数据
维普
