Clinical observation of Xiaoqinglong Decoction and Sanzi Yangqin Decoction on pediatric cough variant asthma with wind-cold attacking lung syndrome
Objective To observe the effects of Xiaoqinglong Decoction combined with Sanzi Yangqin Decoction on ped-iatric cough variant asthma(CVA)with wind-cold attacking lung syndrome.Methods A total of 92 pediatric CVA with wind-cold attacking lung syndromewere randomly assigned into the control group(n =46)and the treatment group(n =46).The pa-tients in the treatment groupwere additionally given Xiaoqinglong Decoction combined with Sanzi Yangqin Decoction on the basis of conventional treatment.A 4-week treatment was performed in the both groups,aiming to compare the curative effect,the lev-els of forced vital capacity(FVC),forced expiratory volume in one second(FEV1)and peak expiratory flow(PEF),and airway hyperresponsiveness(AHR),as well as the levels of serum interleukin-4(IL-4),IL-5 and peripheral blood eosinophil(EOS)before and after treatment between groups.The recurrence and conduct safety assessments in the two groups were ob-served.Results The total effective rate in the treatment group wasbetter than that in the control group(91.30%[42/46]vs 76.09%[35/46],P<0.05).After treatment,FVC,FEV1 and PEF in the two groups were significantly increased(P<0.05),and the increase was more prevalent in the treatment group(P<0.05).The log minimum dose(Dmin)and provoking dose(PD35)in the two groups were significantly increased(P<0.05),and the increase was more pronounced in the treatment group(P<0.05).The levels of serum IL-4,IL-5 and peripheral blood EOS in the two groups were significantly lower(P<0.05),which were significantly lower in the treatment group than the control group(P<0.05).The recurrence rate of the treat-ment group was significantly lower than the control group(33.33%[8/24]vs 88.24%[15/17],P<0.05).Conclusion For children with CVA with wind-cold attacking lung syndrome,Xiaoqinglong Decoction combined with Sanzi Yangqin Decoction can improve their lung function,reduce AHR,regulate the levels of serum IL-4,IL-5 and peripheral blood EOS,and reduce the recurrence rate,with significant curative effect.
CoughTraditional Chinese medicine therapyDecoctionAsthmaXiaoqinglong DecoctionSanzi Yangqin Decoction