Effects of Zhuyu Tongluo Decoction combined with flunarizine on hemorheology indexes in migraine patients of blood stasis blocking collaterals type
Objective To explore the clinical effect of Zhuyu Tongluo Decoction combined with flunarizine on hemorheo-logy indexes in migraine patients of blood stasis blocking collaterals type.Methods A total of 90 migraine patients were ran-domized 1:1:1 to receive flunarizine(Western medicine[WM]group),Zhuyu Tongluo Decoction(traditional Chinese medicine[TCM]group),or Zhuyu Tongluo Decoction combined with flunarizine(combined group).The treatment was performed for 28 days,aiming to compare curative effects,hemorheology indexes including the levels of 5-hydroxytryptamine(5-HT),endo-thelin-1(ET-1)and calcitonin gene-related peptide(CGRP),as well as headache frequency,headache duration and visual analogue scale(VAS)-headache in the three groups before and after treatment.The incidence of adverse reactions was as-sessed.Results The total effective rate of the combined group was better than that of the WM group and the TCM group(96.67%[29/30]vs 76.67%[23/30]vs 73.33%[22/30],P<0.05).There was no significant difference between WM group and TCM group(P>0.05).After treatment,the whole blood viscosity at high and low shear rates and plasma viscosity in the three groups were significantly lower than those before treat-ment(P<0.05),which in the combined group were more lower than those in the WM group and TCM group(P<0.05),but difference was no significant between WM group and TCM group(P>0.05).The levels of 5-HT,ET-1 and CGRP in the three groups were significantly lower than those before treatment(P<0.05),which in the combined group were more lower than those in WM group and TCM group(P<0.05).The level of 5-HT in WM group was significantly lower than that in TCM group(P<0.05),while there was no significant difference in the levels of ET-1 and CGRP between WM group and TCM group(P>0.05).The headache frequency,headache duration and VAS-headache in the three groups were significantly lower than those before treatment(P<0.05),which in the combined group were significantly lower than those in WM group(P<0.05).The headache duration in the WM group was significantly lower than that in TCM group(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion For migraine patients of blood stasis blocking collaterals type,Zhuyu Tongluo Decoction combined with flunarizine can improve the patient's hemorheology inde-xes,regulate the serum 5-HT,ET-1 and CGRP levels,and reduce headache frequency.
万方数据
维普
