Objective To explore the clinical effect of Zhuyu Tongluo Decoction combined with flunarizine on hemorheo-logy indexes in migraine patients of blood stasis blocking collaterals type.Methods A total of 90 migraine patients were ran-domized 1:1:1 to receive flunarizine(Western medicine[WM]group),Zhuyu Tongluo Decoction(traditional Chinese medicine[TCM]group),or Zhuyu Tongluo Decoction combined with flunarizine(combined group).The treatment was performed for 28 days,aiming to compare curative effects,hemorheology indexes including the levels of 5-hydroxytryptamine(5-HT),endo-thelin-1(ET-1)and calcitonin gene-related peptide(CGRP),as well as headache frequency,headache duration and visual analogue scale(VAS)-headache in the three groups before and after treatment.The incidence of adverse reactions was as-sessed.Results The total effective rate of the combined group was better than that of the WM group and the TCM group(96.67%[29/30]vs 76.67%[23/30]vs 73.33%[22/30],P<0.05).There was no significant difference between WM group and TCM group(P>0.05).After treatment,the whole blood viscosity at high and low shear rates and plasma viscosity in the three groups were significantly lower than those before treat-ment(P<0.05),which in the combined group were more lower than those in the WM group and TCM group(P<0.05),but difference was no significant between WM group and TCM group(P>0.05).The levels of 5-HT,ET-1 and CGRP in the three groups were significantly lower than those before treatment(P<0.05),which in the combined group were more lower than those in WM group and TCM group(P<0.05).The level of 5-HT in WM group was significantly lower than that in TCM group(P<0.05),while there was no significant difference in the levels of ET-1 and CGRP between WM group and TCM group(P>0.05).The headache frequency,headache duration and VAS-headache in the three groups were significantly lower than those before treatment(P<0.05),which in the combined group were significantly lower than those in WM group(P<0.05).The headache duration in the WM group was significantly lower than that in TCM group(P<0.05).There was no significant difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion For migraine patients of blood stasis blocking collaterals type,Zhuyu Tongluo Decoction combined with flunarizine can improve the patient's hemorheology inde-xes,regulate the serum 5-HT,ET-1 and CGRP levels,and reduce headache frequency.
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