Clinical effect of modified Didang Decoction combined with Shoutai Pill for incomplete abortion
Objective To observe the clinical effect of modified Didang Decoction combined with Shoutai Pill for incom-plete abortion(IA).Methods Sixty IA patients were randomly assigned into the treatment group(n = 30)and the control group(n =30).Mifepristone was applied to all recruited patients,and those in the control group and the treatment group were additionally managed by Chanfuan granules and modified Didang Decoction combined with Shoutai Pill,respectively.After treat-ment for 2 weeks,the vaginal bleeding time and menstrual recovery time were recorded,the changes in beta-human chorionic gonadotropin(β-hCG),endometrial thickness and uterine artery blood flow parameters on week 1were compared,and the changes in menstrual volume before treatment and during follow-up,and traditional Chinese medicine(TCM)syndrome score before and after treatment were counted between groups,The curative effect on weeks 1 and 2 was assessed.Results The effec-tive rate on week 1 was better in the treatment group(compared with the control group(86.7%[26/30])vs 70.0%[21/30],(P<0.05).The difference was no statistically significant in the overall effective rate on week 2 between the treatment group and the control group(100%[30/30]vs 96.7%[29/30],[P>0.05],respectively).The vaginal bleeding time was significantly shorter in the treatment group than in the control group(P<0.05).While,the menstrual recovery time in the both groups was delayed,and with no statistically significant difference(P>0.05).No difference in the mean level of serum β-hCG differed significantly between groups(P>0.05).None of the endometrial thickness on week 1 differed significantly be-tween groups(P>0.05).The endometrial thickness on week2 in the both groups was significantly increased than that on week 1(P<0.05),which,on week2,was significantly higher in the treatment group than that of the control group(P<0.05).Af-ter treatment,resistance index(RI)of uterine artery blood flow,pulsatility index(PI)of uterine artery,peak systolic velocity/end diastolic velocity(S/D)of helicine arteries in the both groups significantly improved(P<0.05),the improvements in the treatment group were significantly better than those of the control group(P<0.05).The difference was no statistically significant in the menstrual volume score before treatment and during follow-up in the treatment group(P>0.05).The menstrual volume score during follow-up in the control group was significantly lower than that before treatment(P<0.05).There was significant difference in the menstrual volume score during follow-up between groups(P<0.05).During follow-up,patients in the treat-ment group had significantly lower TCM syndrome(abdominal distension pain,lumbosacral pain,breast distension pain)score than before treatment(P<0.05),but patients in the control group had significantly higher TCM syndrome(abdominal disten-sion pain,lumbosacral pain,postmenstrua score)score(P<0.05)than before treatment.The difference was statistically signif-icant in TCM syndrome(abdominal distension pain,lumbosacral pain,postmenstrua score)score between groups(P<0.05).Conclusion For IA patients,modified Didang Decoction combined with Shoutai Pill can shorten vaginal bleeding time,reduce serum β-HCG level,promote endometrial regeneration,and improve uterine artery blood flow parameters.
Induced abortionTraditional Chinese medicine therapyDidang DecoctionShoutai Pill
万方数据
维普
