Efficacy of Wumei Pills in the treatment of gastroesophageal reflux disease of cold and heat miscellaneous type
Objective To investigate the clinical efficacy of Wumei Pills in the treatment of gastroesophageal reflux dis-ease(GERD)of cold and heat miscellaneous type.Methods One hundred and forty-four GERD patients with cold and heat miscellaneous type were randomly assigned into the control group(n =72)and the treatment group(n =72).All patients were given Western medicine,and patients in the treatment group were additionally given Wumei Pills,the treatment was performed for 8 weeks.The key observation was the gastroesophageal reflux disease questionnaire(GerdQ)score,traditional Chinese medi-cine(TCM)syndrome score,endoscopic mucosal grading,and Pittsburgh sleep quality index(PSQI)score.The esophageal ki-netic index including esophageal contraction amplitude,peristaltic wave amplitude,as well as serum gastrointestinal hormones melatonin(MLT),gastrin(GAS),vasoactive peptide(VIP),serum calcitonin gene-related peptide(CGRP),substance P(SP),and 5-hydroxytryptamine(5-HT)]were assessed in the two groups before and after treatment.Results The total ef-fective rate in the treatment group was better than that of the control group(97.2%[70/72]vs 87.5%[63/72],P<0.05).After treatment,the scores of GerdQ,TCM syndrome and PSQI score in the two groups were significantly lower(P<0.05),and the decrease in the treatment group was more significant(P<0.05).After treatment,the mucosal grading in the two groups was significantly improved(P<0.05),and the improvement in the treatment group was more obvious(P<0.05).The esophageal contraction amplitude and peristaltic wave amplitude in the two groups were significantly higher(P<0.05),and the increase in the treatment group was more obvious(P<0.05).Significantly increased GAS,MLT(P<0.05)and significantly decreased VIP(P<0.05)were detected in the two groups after treatment.The treatment group was superior to the control group in GAS,MLT,VIP(all P<0.05).CGRP,SP,5-HT in the two groups were significantly lower(P<0.05),and the decrease in the treatment group was more obvious(P<0.05).Conclusion For GERD patients with cold and heat miscellaneous type,Wumei Pills can relieve symptoms,improve sleep quality,reduce visceral sensitivity,and improve gastrointestinal hormone levels.
万方数据
维普
