Clinical efficacy of modified Qingre Baidu Decoction on postoperative patients with granulomatous lobular mastitis
Objective To explore the clinical efficacy of modified Qingre Baidu Decoction on postoperative patients with granulomatous lobular mastitis(GLM).Methods Totally 120 GLM patients were randomly divided into the exposure group(n =75)and the non-exposure group(n =45).After surgery,all patients were treated with modified Qingre Baidu Decoction.The treatment time of the exposure group and the non-exposure group was no less than 3 months and less than 3 months,respec-tively.The clinical efficacy,recovery of postoperative breast appearance,and the recurrence rate of 3-month follow-up were compared between groups.The correlation between age,body mass index(BMI),the length of traditional Chinese medicine(TCM)treatment,the history of breast feeding,milk stasis,oral contraceptives,wound healing,nipples depression,nipple dis-charge,limb erythema nodosum,allergic diseases,with the recurrence was analyzed.The medication safety was assessed.Re-sults The difference was not statistically significant in the incidence of thrombocytopenia between the exposure group and the non-exposure group(100%[75/75]vs100%[45/45],[P>0.05],respectively).The breast appearance in the exposure group was significantly better than that of the non-exposure group(P<0.05).The recurrence rate in the exposure group was significantly lower than that in the non-exposure group(1.33%[1/75]vs 13.33%[6/45],[P<0.05],respectively).Af-ter treatment,usage time of modified Qingre Baidu Decoction,history of oral contraceptives,allergic diseases might be risk fac-tors for GLM recurrence(P<0.05).Usage time of modified Qingre Baidu Decoction≥3 months was an independent protective factor for GLM recurrence(P<0.05).The safety indexes of the both groups were in reference range,indicating clinical safety.Conclusion For postoperative patients with granulomatous lobular mastitis,usage time of modified Qingre Baidu Decoction≥3 months can significantly improve the treatment effect,protect the breast shape and reduce the recurrence rate of disease to a certain extent,which is safe and effective in clinic.
万方数据
维普
