首页|明目熏眼方雾化熏蒸治疗肝肾阴虚型干眼症临床研究

明目熏眼方雾化熏蒸治疗肝肾阴虚型干眼症临床研究

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目的 观察明目熏眼方雾化熏蒸治疗肝肾阴虚型干眼症的临床疗效.方法 选取2021 年6 月至2022 年6 月收治的62 例肝肾阴虚型干眼症患者为研究对象,按照随机数字表法分为2 组,在均予玻璃酸钠滴眼液联合睑板腺按摩治疗的基础上,对照组31 例(62 眼)予蒸馏水雾化熏蒸治疗,治疗组31 例(62 眼)予明目熏眼方雾化熏蒸治疗.2 组均治疗4 周后统计疗效,比较2 组治疗前后眼表疾病指数(OSDI)评分、泪液分泌试验、泪膜破裂时间(BUT)、角膜荧光素钠染色(FL)评分、明视持久度及美国国立眼科研究所视觉相关生命质量量表(NEI-vFQ-25)评分变化情况,并统计2 组治疗期间睑板腺功能异常检出率.结果 与本组治疗前比较,2 组治疗后OSDI评分均降低(P<0.05),且治疗组治疗后OSDI评分低于对照组(P<0.05).与本组治疗前比较,2 组治疗后泪液分泌试验长度均增加(P<0.05),且治疗组治疗后泪液分泌试验长度大于对照组(P<0.05).与本组治疗前比较,2 组治疗后BUT均变长(P<0.05),且治疗组治疗后BUT长于对照组(P<0.05).与本组治疗前比较,2 组治疗后FL评分均降低(P<0.05),且治疗组治疗后FL评分低于对照组(P<0.05).与本组治疗前比较,2 组治疗后明视持久度均升高(P<0.05),且治疗组治疗后明视持久度高于对照组(P<0.05).与本组治疗前比较,2 组治疗后NEI-VFQ-25 评分均升高(P<0.05),且治疗组治疗后NEI-VFQ-25 评分高于对照组(P<0.05).治疗组睑板腺功能异常检出率20.97%(13/62),对照组睑板腺功能异常检出率38.71%(24/62),治疗组睑板腺功能异常检出率低于对照组(P<0.05).结论 明目熏眼方雾化熏蒸治疗干眼症疗效确切,可有效改善患者眼部症状,提高泪膜稳定性,保护角膜上皮细胞完整,增加明视持久度,改善生活质量,降低睑板腺功能异常风险.
Clinical study on fumigation therapy of Mingmu Xunyan Recipe on dry eye syndrome of liver-kidney yin deficiency type
Objective To observe the efficacy of fumigation therapy of Mingmu Xunyan Recipe on dry eye syndrome of liver-kidney yin deficiency type.Methods Sixty-two patients with dry eye syndrome(124 eyes)treated in our hospital from June 2021 to June 2022 were enrolled,they were randomized 1∶1 to the control group(n =31,62 eyes)or research group(n =31,62 eyes).All patients were given massage at meibomian gland,and those in the control group and the research group were additionally given fumigation therapy of distilled water and self-made Mingmu Xunyan Recipe,respectively.The curative effect was statistically analyzed after 4 weeks of treatment.The ocular surface disease index(OSDI)score,tear secretion test(TST),tear break-up time(BUT),corneal fluorescein staining(FL)score,and duration of photopic vision(DPV)were in-cluded as comparators before and after treatment between groups.The detection rate of meibomian gland dysfunction during treat-ment was counted.Results After treatment,the patients in the both groups presented significantly decreased OSDI scores(P<0.05),significantly increased TST(P<0.05),significantly longer BUT(P<0.05),significantly reduced FL score(P<0.05),significantly increased DPV(P<0.05),and significantly increased National Eye Institute Visual Functioning Question-naire-25(NEI VFQ-25)score(P<0.05)than those before treatment(P<0.05),and the improvements were more pro-nounced in the treatment group relative to the control group(all P<0.05).The detection rate of meibomian gland dysfunction in the treatment group was significantly lower than that in the control group(20.97%[13/62]vs 38.71%[24/62],P<0.05).Conclusion The fumigation therapy of self-made Mingmu Xun-yan Recipe is effective in treating dry eye syndrome.It can effectively improve patients'eye symptoms,improve tear film stabili-ty,protect the integrity of corneal epithelial cells,increase the duration of photopic vision,improve quality of life,and reduce risk for meibomian gland dysfunction.

Dry eye syndromeFumigation therapyLiver-kidney yin deficiencyChinese medicine therapy

陆瑶瑶、吴勤、杨春林

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江苏省启东市中医院眼科,江苏 启东 226200

干眼症 熏蒸疗法 肝肾阴虚 中药疗法

江苏省南通市科技局项目

MSZ2022153

2024

河北中医
河北省医学情报研究所,河北省中医药学会

河北中医

CSTPCD
影响因子:0.951
ISSN:1002-2619
年,卷(期):2024.46(4)
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