Clinical study on fumigation therapy of Mingmu Xunyan Recipe on dry eye syndrome of liver-kidney yin deficiency type
Objective To observe the efficacy of fumigation therapy of Mingmu Xunyan Recipe on dry eye syndrome of liver-kidney yin deficiency type.Methods Sixty-two patients with dry eye syndrome(124 eyes)treated in our hospital from June 2021 to June 2022 were enrolled,they were randomized 1∶1 to the control group(n =31,62 eyes)or research group(n =31,62 eyes).All patients were given massage at meibomian gland,and those in the control group and the research group were additionally given fumigation therapy of distilled water and self-made Mingmu Xunyan Recipe,respectively.The curative effect was statistically analyzed after 4 weeks of treatment.The ocular surface disease index(OSDI)score,tear secretion test(TST),tear break-up time(BUT),corneal fluorescein staining(FL)score,and duration of photopic vision(DPV)were in-cluded as comparators before and after treatment between groups.The detection rate of meibomian gland dysfunction during treat-ment was counted.Results After treatment,the patients in the both groups presented significantly decreased OSDI scores(P<0.05),significantly increased TST(P<0.05),significantly longer BUT(P<0.05),significantly reduced FL score(P<0.05),significantly increased DPV(P<0.05),and significantly increased National Eye Institute Visual Functioning Question-naire-25(NEI VFQ-25)score(P<0.05)than those before treatment(P<0.05),and the improvements were more pro-nounced in the treatment group relative to the control group(all P<0.05).The detection rate of meibomian gland dysfunction in the treatment group was significantly lower than that in the control group(20.97%[13/62]vs 38.71%[24/62],P<0.05).Conclusion The fumigation therapy of self-made Mingmu Xun-yan Recipe is effective in treating dry eye syndrome.It can effectively improve patients'eye symptoms,improve tear film stabili-ty,protect the integrity of corneal epithelial cells,increase the duration of photopic vision,improve quality of life,and reduce risk for meibomian gland dysfunction.
Dry eye syndromeFumigation therapyLiver-kidney yin deficiencyChinese medicine therapy