Clinical study on Huoli Gukang Formula on primary osteoporosis and its influence on bone turnover markers
Objective To explore the clinical research of Huoli Gukang Formula on primary osteoporosis and its influ-ence on bone turnover markers.Methods Forty patients with primary osteoporosis who visited our hospital from January 2021 to December 2021 were selected as the research subjects.They were randomly assigned into the control group(routine Western medicine[RWM],n =20)or the treatment group(Huoli Gukang Formula +RWM,n =20).A 9-month treatment and 6-month follow-up were performed.Before treatment and at 1 and 6 months of follow-up,the scores of pain visual analogue scale(VAS)and Oswestry Disability Index(ODI)questionnaires,the T value of bone mineral density(BMD),the serum levels of total procollagen type 1 N-terminal propeptide(t-P1NP)and beta-isomerized C-terminal telopeptide of type I collagen(β-CTX)in bone turnover markers were included as comparators between the two groups.Results At 1 and 6 months of fol-low-up,the VAS and ODI scores in the two groups were significantly lower than those before treatment(P<0.05),which in the treatment group decreased significantly compared to the control group(P<0.05).The T value of BMD of lumbar vertebrae L1-L4,right hip and right femoral neck at 6 months of follow-up in the both groups was significantly higher than that before treatment(P<0.05),and the treatment group was superior to the control group for the T value of BMD(P<0.05).The levels of t-PINP at 1 and 6 months of follow-up in the both groups were significantly higher than those before treatment,and the improve-ment was more pronounced in treatment group than in the control group(P<0.05).The level of β-CTX at1 and6 months of fol-low-up in the both groups was significantly decreased than before treatment(P<0.05),which was significantly lower in the treatment group relative to the control group(P<0.05).Conclu-sion The application of Huoli Gukang Formula has exact curative for primary osteoporosis,which can effectively relieve clinical symptoms,improve bone turnover,and increase bone density.It is capable increasing t-P1NP,promoting bone formation,re-ducing β-CTX,and inhibiting bone resorption.
OsteoporosisBone formationBone resorptionChinese medicine therapy