Efficacy and potential mechanisms of Bushen Huoxue Shugan Decoction combined with Western medicine on Parkinson's disease
Objective To investigate the clinical effect and potential mechanisms of Bushen Huoxue Shugan Decoction combined with Western medicine in the treatment of Parkinson's disease(PD).Methods From January 2021 to May 2022,ninety-six PD patients admitted to our hospital were enrolled as the research subjects,they were randomly assigned into the con-trol group(routine Western medicine[RWM],n =48)or the treatment group(Bushen Huoxue Shugan Decoction plus RWM,n = 48),the efficacy was statistically analyzed after 3 months of treatment.Neurotransmitters(including serum 5-hydroxytryptamine[5-HT],norepinephrine[NE],and dopamine[DA]),neurotrophic factors(including serum nerve growth factor[NGF],brain-derived neurotrophic factor[BDNF],and glial cell line-derived neurotrophic factor[GDNF]),quality of life(including daily living conditions,mental health,humiliation,cognition,communication,social support,physical activi-ty,and physical discomfort in the Parkinson's Disease Questionnaire39[PDQ-39]),and disease severity(non-motor symp-toms,activities of daily living,and motor symptom scores in the Movement Disorder Society Unified Parkinson's Disease Rating Scale[MDS-UPDRS])were included as comparators between the two groups before and after treatment.Results The total ef-fective rate in the treatment group was significantly higher than that of the control group(95.83%[46/48]vs77.08%[37/48],P<0.05).The patients in the both group presented significantly elevated levels of 5-HT,NE and DA,significantly higher levels of NGF,BDNF and GDNF,significantly increased PDQ-39 score,and significantly decreased MDS-UPDRS score than those before treatment(all P<0.05),and the improvements were more pronounced in the treatment group relative to the control group(all P<0.05).Conclusion The combination of Bushen Huoxue Shugan Decoction and Western medicine has ex-act curative for PD,it can effectively improve their quality of life and clinical symptoms by increasing the levels of 5-HT,NE and DA,correcting the disorder of neurotransmitter network,increasing the levels of NGF,BDNF and GDNF,and promoting nerve cell repair.
Parkinson's diseaseNeurotransmitterNeurotrophic factorIntegrative medicine therapy
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