Effect of hot compress therapy of Jianlou Recipe combined with aspirin enteric-coated tablets on internal fistula func-tion in uremia patients with arteriovenous fistulaplasty
Objective To observe the effect of hot compress therapy of Jianlou Recipe combined with aspirin enteric-coated tablets on internal fistula function in uremia patients with arteriovenous fistulaplasty(AVF).Methods Eighty uremia patients with AVF admitted from July 2019 to July 2021 were enrolled as the research subjects,theywere randomized1:1 to the control group(aspirin enteric-coated tablets)or the treatment group(hot compress therapy of JianlouRecipeplus aspirin enteric-coated tablets).The therapeutic effects were calculated after 1-month of treatment.Before treatment and on weeks 1,2,3,and 4 of treatment,the fistula blood flow,internal fistula diameter,and vascular endothelial function indicators(including endothelin-1[ET-1],nitric oxide[NO]),vascular elasticity,vascular murmur,patency rate of internal fistula,and inci-dence of complications were included as comparators between groups.After 1 year of follow-up,the rates of fistula disfunction and reconstructionwereassessed between groups.Results After treatment,the 1-,2-,3-,4-week blood flow and diame-ter of the internal fistula in the both groups were significantly greater than those before treatment(P<0.05),which was more pronounced in the treatment group than in the control group(P<0.05).Significantlylowerthe 1-,2-,3-,4-week ET-1 and higher NO were detected in the both groups than those before treatment(both P<0.05),the difference in the levels of ET-1 and NO was significant between groups(both P<0.05).The excellent rate of vascular elasticity(92.50%[37/40]vs 70.00%[28/40]and the rate of vascular murmur(90.00%[36/40]vs 72.50%[29/40])in the treatment group were superior to the control group(P<0.05).The patency rate of inter-nal fistula in the treatment group was significantly higher than that of the control group(92.50%[37/40]vs 72.50%[29/40],P<0.05).The total incidence of complications in the treatment group was significantly lower than that of the control group(2.50%[1/40]vs 20.00%[8/40],P<0.05).The rate of fistula disfunction or reconstruction within 1 year of follow-up in the treatment group was significantly lower than that of the control group(5.00%[2/40]vs 25.00%[10/40],P<0.05).Conclusion Hot compress therapy of Jianlou Recipe combined with aspirin enteric-coated tablets has effective in uremia patients with AVF.It can effectively improve the internal fistula diameter,increase the blood flow of arteriovenous fistula,increase vascular elasticity,reduce vascular murmur,maintain the patency of internal fistula,and reduce complications,with a reliable long-term effect.It is capable to prevent thrombosis by improving the indicators of vascular endothelial function.
UremiaArteriovenous anastomosisAspirinTraditional Chinese medicine therapy
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