Effect of Peiyuan Kangai Decoction on radiation-induced lung injury in advanced non-small cell lung cancer
Objective To observe the improvement effect of Peiyuan Kangai Decoction on radiation-induced lung inju-ry(RILI)in advanced non-small cell lung cancer(NSCLC).Methods A total of 88 advanced NSCLC patients with RILI ad-mitted to our hospital from January 2020 to January 2022 were enrolled as the study control.They were randomized to control group(routine Western medicine(RWM),n =44)and treatment group(Peiyuan Kangai Decoction plus RWM,n =44).The aim was to compare RILI-related indexes(including soluble vascular cell adhesion molecule-1[sVCAM-1],interleukin-17 A[IL-17A],high mobility group protein[HMGB1],IL-1β,vascular endothelial growth factor[VEGF],CD34,CD105,transforming growth factor-β1[TGF-β1]and arterial partial pressure of oxygen[PaO2]),oxidative stress indexes(including superoxide dismutase[SOD],glutathione peroxidase[GSH-Px],and reactive oxygen species[ROS]),immune function indexes(including T lymphocyte subsets CD4+,CD8+ and T helper 1[Th1]/Th2),and the RILI degree between the two groups before and after treatment.Results After treatment,the levels of sVCAM-1,IL-17 A,HMGB1,IL-1β,CD105 and TGF-β1 in the two groups were significantly decreased(P<0.05),and the levels of CD34,VEGF and PaO2 were significantly increased(P<0.05).There were significant differences in sVCAM-1,IL-17A,HMGB1,IL-1β,CD105 and TGF-β1,as well as CD34,VEGF and PaO2 between groups(all P<0.05).After treatment,the levels of SOD and GSH-Px in the two groups elevated significantly(P<0.05),and the levels of ROS reduced significantly(P<0.05).The differences in SOD,GSH-Px,and ROS were significant between groups(all P<0.05).After treatment,significantly increased CD4+,and signifi-cantly decreased CD8+ and Th1/Th2 were detected in the two groups(all P<0.05).The treatment group was superior to the control group for CD4+,CD8+,and Th1/Th2(all P<0.05).The injury rate of mild RILI in the two groups was significantly higher than before treatment(P<0.05),and the improvement was more pronounced in the treatment group compared with the control group(P<0.05).Conclusion For advanced NSCLC patients with RILI,Peiyuan Kangai Decoction has a definite effect,it can effectively inhibit inflammatory response,reduce oxidative stress injury,improve immune status and reduce the de-gree of lung injury.
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