Efficacy of Zengsui Shengbai Decoction combined with conventional Western medicine on post-chemotherapy myelo-suppression in patients with primary hepatic carcinoma of spleen-kidney yang deficiency syndrome
Objective To investigate the efficacy of Zengsui Shengbai Decoction combined with conventional Western medicine(CWM)on post-chemotherapy myelosuppression in patients with primary hepatic carcinoma(PHC)of spleen-kid-ney yang deficiency syndrome.Methods Totally 86 patients with PHC(spleen-kidney yang deficiency syndrome)underwent transcatheter arterial chemoembolization(TACE)in our hispital,they had myelosuppression after chemotherapy.The patients were randomly assigned to receive CWM(the treatment group,n=43)or CWM combined with Zengsui Shengbai Decoction(the control group,n=43).The treatment lasted until that the blood cells(white blood cell count[WBC],platelet count[PLT])returned to normal range.The recovery time of blood cells and the blood routine examination including WBC,PLT,hemoglobin(Hgb),neutrophils(N)were compared between the two groups.Karnofsky Performance Status(KPS)and traditional Chinese medicine(TCM)syndrome score were compared,and TCM curative effect and clinical efficacy were assessed.Results The curative effect in the treatment group was significantly better than that in the control group(total effective rate of TCM syndromes:86.05%[37/43]vs 67.44%[29/43],clinical efficacy rate:97.67%[42/43]vs 83.72%[36/43],both P<0.05).The recovery time of WBC and PLT in the treatment group was significantly shorter than that in the control group(P<0.05).The levels of WBC,PLT,Hgb,N in the both groups on days 3 and 7 were significantly higher than those on day 0 and on day 1(P<0.05),and which on day 7 were significantly higher than those on day 3(P<0.05).The levels of WBC,PLT,Hgb,N in the treatment group on days 3 and 7 were significantly higher than those in the control group(P<0.05).On day 7,significantly increased KPS scores and significantly decreased TCM syndrome scores were found in the both groups than those on day 0(all P<0.05),and the treatment group was superior to the control group for KPS and TCM syndrome scores(all P<0.05).Con-clusion Zengsui Shengbai Decoction combined with CWM can effectively shorten recovery time of blood cells in treating post-chemotherapy myelosuppression in patients with PHC(spleen-kidney yang deficiency syndrome),improve blood routine,physi-cal status and TCM symptoms,and enhance clinical efficacy.
Primary hepatic carcinomaMyelosuppressionSpleen-kidney yang deficiency syndromeTraditional Chi-nese medicine therapy
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