不同中医证型急性脑梗死患者血浆小而密低密度脂蛋白胆固醇、脂蛋白a表达情况与神经功能缺损和转归的关系
Relationship between small dense low-density lipoprotein cholesterol and lipoprotein(a)with the neurologic impair-ment and recovery in patients with acute cerebral infarction of different traditional Chinese medicine syndrome
李艳红 1黄志成2
作者信息
- 1. 湖北省武汉市武昌医院和武汉科技大学附属武昌医院中医科,湖北 武汉 430063
- 2. 湖北省武汉长动医院康复医学科,湖北 武汉 430074
- 折叠
摘要
目的 研究不同中医证型急性脑梗死(ACI)患者血浆小而密低密度脂蛋白胆固醇(sdLDL-C)、脂蛋白a(Lpa)表达情况与神经功能缺损和转归的关系.方法 选取120 例ACI患者作为研究对象,另选取同期健康体检的志愿者120 例作为对照组,比较观察组与对照组及观察组内不同中医辨证、不同预后、不同程度神经功能损伤患者血浆sdLDL-C、Lpa水平之间的差异,并对观察组血浆sdLDL-C、Lpa水平与美国国立卫生研究院卒中量表评分(NIHSS)、改良Rankin评分(mRs)评分进行相关性分析.结果 观察组血浆sdLDL-C、Lpa水平高于对照组(P<0.05).观察组不同证型患者血浆sdLDL-C、Lpa水平比较差异有统计学意义(P<0.05),血浆sdLDL-C、Lpa水平从高到低依次为风痰瘀阻型、风火上扰型、阴虚风动型.观察组不同证型患者NIHSS、mRs评分比较差异有统计学意义(P<0.05),NIHSS、mRs评分从高到低依次为风痰瘀阻型、风火上扰型、阴虚风动型.观察组预后不良的患者血浆sdLDL-C、Lpa水平高于预后良好的患者(P<0.05).观察组不同程度神经功能损伤患者血浆sdLDL-C、Lpa水平比较差异有统计学意义(P<0.05),血浆sdLDL-C、Lpa水平从低到高依次为轻度神经功能损伤、中度神经功能损伤、重度神经功能损伤患者.相关性分析结果显示,观察组血浆sdLDL-C、Lpa水平与NIHSS、mRs评分呈现显著的负相关性(P<0.05).结论 不同中医证型ACI患者血浆sdLDL-C、Lpa表达呈现显著的差异,血浆sdLDL-C、Lpa与神经功能缺损和转归呈现显著的负相关性,sdLDL-C、Lpa水平越高,预后越差.
Abstract
Objective To investigate the relationship between the expression of small dense low-density lipoprotein cholesterol(sdLDL-C)and lipoprotein(a)(Lp[a])with the neurologic impairment and recovery in patients with acute cere-bral infarction(ACI)of different traditional Chinese medicine(TCM)syndrome.Methods Totally 120 ACI patients and 120 healthy physical examination volunteers in the same period were selected as the observation group and the control group,respec-tively.The differences in sdLDL-C and Lp(a)among ACI patients with different TCM syndrome,different prognosis,and dif-ferent neurologic impairment were compared.The correlation between plasma sdLDL-C,Lp(a)and National Institutes of Health Stroke Scale(NIHSS),modified Rankin scale(mRS)was analyzed.Results The plasma sdLDL-C and Lp(a)levels in observation group were significantly higher than those in control group(P<0.05).There were statistically significant differ-ences in sdLDL-C,Lp(a),NIHSS and mRs scores in patients with different TCM syndrome(all P<0.05).The sdLDL-C,Lp(a),NIHSS and mRs scores of patients with different TCM syndrome from high to low were phlegm wind resistance type,wind-fire ascending syndrome and Yin deficiency wind-moving type.The plasma levels of sdLDL-C and Lp(a)in patients with poor prognosis were significantly higher than those in patients with good prognosis(P<0.05).The difference was statistically significant in plasma sdLDL-C and Lp(a)levels in patients with different neurologic impairment of the observation group(P<0.05).The plasma sdLDL-C and Lp(a)levels of patients with different neurologic impairment from low to high were mild,moderate and severe neurologic impairment.The correlation analysis showed that plasma sdLDL-C and Lp(a)levels were sig-nificantly correlated with NIHSS and mRs scores in the observation group(P<0.05).Conclusion The expressions of plasma sdLDL-C and Lp(a)in ACI patients with different TCM syndrome were significantly different,and the plasma sdLDL-C and Lp(a)levels in the body were significantly correlated with neurologic impairment and recovery.The higher the plasma sdLDL-C and Lp(a),the worse the prognosis.
关键词
中医辨证/急性脑梗死/神经功能损伤Key words
Traditional Chinese medicine syndrome differentiation/Acute cerebral infarction/Lp(a)/sdLDL-C/Neurologic impairment引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据