Relationship between small dense low-density lipoprotein cholesterol and lipoprotein(a)with the neurologic impair-ment and recovery in patients with acute cerebral infarction of different traditional Chinese medicine syndrome
Objective To investigate the relationship between the expression of small dense low-density lipoprotein cholesterol(sdLDL-C)and lipoprotein(a)(Lp[a])with the neurologic impairment and recovery in patients with acute cere-bral infarction(ACI)of different traditional Chinese medicine(TCM)syndrome.Methods Totally 120 ACI patients and 120 healthy physical examination volunteers in the same period were selected as the observation group and the control group,respec-tively.The differences in sdLDL-C and Lp(a)among ACI patients with different TCM syndrome,different prognosis,and dif-ferent neurologic impairment were compared.The correlation between plasma sdLDL-C,Lp(a)and National Institutes of Health Stroke Scale(NIHSS),modified Rankin scale(mRS)was analyzed.Results The plasma sdLDL-C and Lp(a)levels in observation group were significantly higher than those in control group(P<0.05).There were statistically significant differ-ences in sdLDL-C,Lp(a),NIHSS and mRs scores in patients with different TCM syndrome(all P<0.05).The sdLDL-C,Lp(a),NIHSS and mRs scores of patients with different TCM syndrome from high to low were phlegm wind resistance type,wind-fire ascending syndrome and Yin deficiency wind-moving type.The plasma levels of sdLDL-C and Lp(a)in patients with poor prognosis were significantly higher than those in patients with good prognosis(P<0.05).The difference was statistically significant in plasma sdLDL-C and Lp(a)levels in patients with different neurologic impairment of the observation group(P<0.05).The plasma sdLDL-C and Lp(a)levels of patients with different neurologic impairment from low to high were mild,moderate and severe neurologic impairment.The correlation analysis showed that plasma sdLDL-C and Lp(a)levels were sig-nificantly correlated with NIHSS and mRs scores in the observation group(P<0.05).Conclusion The expressions of plasma sdLDL-C and Lp(a)in ACI patients with different TCM syndrome were significantly different,and the plasma sdLDL-C and Lp(a)levels in the body were significantly correlated with neurologic impairment and recovery.The higher the plasma sdLDL-C and Lp(a),the worse the prognosis.
Traditional Chinese medicine syndrome differentiationAcute cerebral infarctionLp(a)sdLDL-CNeurologic impairment
NETL
NSTL
万方数据
