Effect of kidney-deficiency blood-stasisprescription combined with kidney-warming and pregnancy-promoting moxibustion on ovulation and pregnancy outcome in patients with endometriosis cyst complicated with infertility
Objective To analyze the effect of kidney-deficiency blood-stasisprescription combined with kidney-warming and pregnancy-promoting moxibustion on ovulation and pregnancy outcome in endometriosis cyst complicated with infer-tility.Methods Forty patients with endometriotic cysts and infertility were randomly divided into the control group(20 cases)and the treatment group(20 cases).All patients were treated with oxaliplatin acetate(Noride),those in the treatment group were additionally treated with kidney-deficiency blood-stasisprescription combined with kidney-warming and pregnancy-pro-moting moxibustion.Both groups were treated for 3 menstrual cycles.The traditional Chinese medicine(TCM)syndrome scores,diameter of endometriotic cysts,visual analogue scale(VAS)scores,and ovarian function indicators(serum luteinizing hormone[LH],estradiol[E2],follicle stimulating hormone[FSH])were included as comparatorsbetween two groups before and after treat-ment.The clinical efficacy,ovulation rate,ovulation number the clinical efficacy,1-year clinical pregnancy rateand early miscar-riage rate of the two groups were statistically analyzed.Results The total effective rate in the treatment group was significantly higher than that of the control group(95.00%[19/20]vs 65.00%[13/20],P<0.05).After 1 and 3 courses of treatment,the TCM syndrome dimension score,diameter of endometriosis cyst,and VAS for pain score in both groups were significantly lower than before treatment(P<0.05),and the decreases were more pronounced in the treatment group relative to the control group(P<0.05).The ovulation rate of the treatment group was significantly higher than that of the control group(90.00%[18/20]vs 60.00%[12/20],P<0.05),and the number of ovulations in the treatment group was significantly higher than that of the control group(P<0.05).After1 and3 courses of treatment,the serum levels of LH and FSH in both groups were significantly higher than those before treatment(P<0.05),while the serum levels of E2 were significantly lower(P<0.05),and there were differences in serum levels of LH,FSH and E2 between the two groups(all P<0.05).The 1-year clinical pregnancy rate in the treatment group was significantly higher than that of the control group(P<0.05),and there was no statistically significant differ-ence in 1-year early abortion rate between groups(P>0.05).Conclusion For patients with endometriotic cysts and infertility,kidney-deficiency and blood-stasis prescription combined with kidney-warming and pregnancy-promoting moxibustion can effectively relieve the symptoms of endometriosis cyst complicated with infertility,such as waist and abdomen pain,irregular menstruation.It is capable of reducing the diameter of the cyst,improving the ovulation rate and clinical pregnancy rate,impro-ving the ovarian index and pregnancy outcome,and the clinical effect is significant.
Endometriosis cystInfertilityKidney-deficiency and blood-stasis prescriptionKidney-warming and pregnancy-promoting moxibustionOvulationPregnancy Outcome