Clinical effect of Wenfei Huatan Decoction combined with acupoint application on chronic persistent bronchial asthma
Objective To observe the clinical effect of Wenfei Huatan Decoction combined with acupoint application on bronchial asthma.Methods A total of 106 patients with chronic persistent bronchial asthma were randomzied 1∶1 to receive Western medicine treatment(WMT,the control group,3 cases dropped off)or Wenfei Huatan Decoction combined with acupoint application plus WMT(the observation group,2 cases dropped off).The efficacy of traditional Chinese medicine(TCM)syn-dromes were calculated.The changes in immunofactors(interferon[IFN-γ],interleukin-4[IL-4],T helper 17 cells[Th17]/regulatory T cell[Treg]),airway remodeling(matrix metalloproteinase 9[MMP-9],tissue inhibitor of metalloprotei-nase-1[TIMP-1],transforming growth factor-beta1[TGF-β1],and vascular endothelial growth factor[VEGF]),and lung function(forced expiratory volume in the first second[FEV1],forced vital capacity[FVC],peak expiratory velocity[PEF]and the ratio of the first second forced expiratory volume of forced vital capacity[FEV1/FVC])were included as compa-rators before and after treatment.The number of asthma attacks was recorded and the clinical efficacy was assessed.Results After treatment,the TCM syndromes scores in the both groups were significantly lower than those before treatment(P<0.05),and which were significantly lower in the treatment group than in the control group(P<0.05).After treatment,the levels of IFN-γ and Treg in the both groups were significantly increased(P<0.05),while IL-4,Th17 and Th17/Treg were signifi-cantly decreased(P<0.05),and there were significant differences in the above indexes between the two groups(all P<0.05).After treatment,the levels of MMP-9,TIMP-1,TGF-β1 and VEGF were significantly decreased in the both groups than those before treatment(P<0.05),and the decreases were more pronounced relative to the control group(P<0.05).After treatment,the indexes of FEV1,FVC,PEF and FEV1/FVC in the both groups were significantly increased(P<0.05),and the in-creases were more common in treatment group compared to control group(P<0.05).The number of asthma attacks in the treat-ment group was significantly less than that that in the control group(P<0.05).Conclusion Wenfei Huatan Decoction com-bined with acupoint application can improve the symptoms of patients with chronic persistent bronchial asthma,maintain the body's immune balance,reduce airway remodeling,improve lung function,and reduce the number of asthma attacks,with out-standing efficacy.
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