Influences of Zhishao Gancao Decoction and amiodarone on cardiac function,electrocardiogram and serological mark-ers in patients with congestive heart failure and arrhythmian
Objective To investigate the influences of Zhishao Gancao Decoction combined with amiodarone on cardiac function,electrocardiogram(ECG)and serological markers in patients with congestive heart failure and arrhythmia.Methods Eighty patients with congestive heart failure and arrhythmia were divided into in control group(n=40)and combined group(n=40)according to random number table method,all patients were treated with amiodarone,and those in treatment group were ad-ditionally treated with Zhishao Gancao Decoction.A 3-month treatment was performed in the both groups.The frequency and duration of arrhythmias,traditional Chinese medicine(TCM)syndrome score,clinical efficacy,cardiac function(left ventricular end-diastolic diameter[LVEDD],left ventricular end-systolic diameter[LVESD],left ventricular ejection fraction[LVEF],stroke volume[SV])between groups before and after treatment were included as comparators.ECG(heart rate-cor-rected-QT[QTc]interval,heart rate-corrected T-peak to T-end[Tp-Tec])and serological indexes(matrix protease-9[MMP-9],adiponectin[APN],amino-terminal pro-B-type natriuretic peptide precursor[NT-proBNP])were recor-ded,and the curative effects of the two groups were analyzed.Results The total effective rate of the combined group was signifi-cantly higher than that of the control group(87.50%[35/40]vs 65.00%[26/40],P<0.05).The patients in the both group presented significantly decreased the frequency and duration of ar-rhythmias,the score of TCM syndrome,the levels of LVEDD,LVESD compared with before treatment(all P<0.05),and the improvements were more pronounced in the combined group(all P<0.05).The patients in the both groups had significantly in-creased LVEF and SV,significantly decreased QTc,Tp-Tec,MMP-9,NT-proBNP,and significantly elevated APN(all P<0.05),the combined group was superior to the control group for the above indexes(P<0.05).Conclusion Zhishao Gan-cao Decoction combined with amiodarone for arrhythmia in congestive heart failure can effectively improve the patient's cardiac function,ameliorate clinical symptoms and ECG,and regulate serological indicators,it has a good effect.
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