Clinical efficacy of Guipi Peiyuan Decoction combined with moxibustion for advanced cancer cachexia of speen-kidney dificiency
Objective To observe the clinical efficacy of Guipi Peiyuan Decoction combined with moxibustion for ad-vanced cancer cachexia(speen-kidney dificiency).Methods Eighty patients with advanced cancer cachexia(speen-kidney dificiency)were randomly assigned into treatment group(n=40)and control group(n=40).All patients were managed by conventional nutritional support,and those in control group and treatment group were additionally treated with oral megestrol ace-tate dispersible tablets and Guipi Peiyuan Decoction combined with moxibustion at Zusanli(ST36)and Yongquan(KI1),re-spectively.Treated for 4 weeks,the aim was to compare traditional Chinese medicine(TCM)syndrome scores,cellular immune function(T lymphocyte subsets CD3+,CD4+,CD8+,CD4+/CD8+),and nutritional indicators[hemoglobin[Hgb],albumin[ALB],prealbumin[PA],leptin[LP],body weight)between groups before and after treatment.The curative effect was as-sessed.Results The overall effective rate in the treatment group was better than that in the control group(77.50%[31/40]vs 55.00%[22/40],[P<0.05],respectively).After treatment,TCM symptom scores in the both groups were significantly de-creased(P<0.05),The domain scores of TCM syndromes(inappetence,physical fatigue,weak waist and knees,mental fa-tigue and lazy words)score and total score decreased notably in the treatment group compared with the control group(P<0.05).After treatment,significantly increased CD3+,CD4+,CD4+/CD8+,and decreased CD8+were found in the treatment group,and the improvements were more pronounced in the treatment group than those of the control group(P<0.05).The levels of Hgb,ALB,PA,LP,and body mass index(BMI)in the treatment group were significantly increased(P<0.05),and which were significantly higher than those in the control group(P<0.05).Conclusion For patients with advanced cancer cachexia(speen-kidney dificiency),Guipi Peiyuan Decoction combined with moxibustion can relieve clinical symptoms,it can increase BMI and improve clinical efficacy by regulating cellular immune function and improving nutritional status.
CancerCachexiaTraditional Chinese medicine therapyMoxibustion
NETL
NSTL
万方数据
